Genetic Polymorphisms in FAS (CD95) and FAS Ligand (CD178) Promoters and Risk of Tobacco-related Oral Carcinoma: Gene–Gene Interactions in High-risk Indians. (25th January 2013)

• Record Type: Journal Article
• Authors: Karimi, Mohammad Yahya; Kapoor, Vaishali; Sharma, Suresh Chandra; Das, Satya Narayan
• Is Part Of: Cancer investigation. Volume 31:Number 1(2013)
• Page Start: 1
• Page End: 6
• Publication Date: 2013-01-25
• Subjects: Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.3109/07357907.2012.743555
• Languages: English
• ISSNs: 0735-7907

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>We assessed the association of functional single nucleotide polymorphisms (SNP) in <italic>FAS</italic> -1377, -670 and <italic>FAS</italic> ligand (<italic>FASL</italic>) -844 promoters in 139 oral cancer patients and 126 normal subjects by PCR-RFLP. In logistic regression analysis <italic>FAS</italic> -1377 GA genotype appeared to marginally increase the risk while <italic>FASL</italic> -844 TC genotype appeared as low risk factor. The combined genotypes <italic>FAS</italic> -1377 GA or AA and <italic>FASL</italic> -844 TT (<italic>p</italic> &lt;0.03), and <italic>FAS</italic> -670 AG or GG and <italic>FASL</italic> -844 TT (<italic>p</italic> &lt;0.007) appeared to double the risk. <italic>FAS</italic> and <italic>FASL</italic> gene–gene and gene–environment interactions seems to modulate susceptibility/resistance to tobacco-related oral cancer in Indians.</p> </abstract>