Quinazoline-sulfonamides as potential antitumor agents: synthesis and biological testing. (April 2013)

• Record Type: Journal Article
• Authors: Alafeefy, Ahmed M.; Alqasoumi, Saleh I.; Ashour, Abdelkader E.; Alshebly, Mashael M.
• Is Part Of: Journal of enzyme inhibition and medicinal chemistry. Volume 28:Number 2(2013:Apr.)
• Page Start: 375
• Page End: 383
• Publication Date: 2013-04
• Subjects: Enzyme inhibitors -- Periodicals; Enzyme Inhibitors -- periodicals; Biochemistry -- periodicals; 572.7
• DOI: 10.3109/14756366.2012.668541
• Languages: English
• ISSNs: 1475-6366

Abstract

<abstract> <title>Abstract</title> <p>New series of quinazoline containing sulfonamide derivatives were prepared and screened for their antitumor activity. Four human cancer cell lines, namely, hepatoma cancer cell line (HepG2), breast cancer cell line (MCF-7), cervix cancer cell line (HeLa) and colon cancer cell line (HCT-8), were used to measure the cytotoxic activity. Compounds <bold>8</bold> and <bold>21</bold> exhibited remarkable antitumor activity almost similar to that of the standard drug (doxorubicin). Six compounds <bold>16</bold>, <bold>22</bold>, <bold>23</bold>, <bold>29</bold>, <bold>30</bold> and <bold>33</bold>, showed considerable activity and few compounds were totally inactive.</p> </abstract>