Relationship of fasting total homocysteine, high sensitivity C-reactive protein and features of the metabolic syndrome in Trinidadian subjects. (February 2013)

• Record Type: Journal Article
• Authors: Nayak, B. S.; Pinto Pereira, L. M.; Seemungal, T.; Davis, G.; Teelucksingh, S.; Jagessar, A.; Legall, G.
• Is Part Of: Archives of physiology and biochemistry. Volume 119:Number 1(2013)
• Page Start: 22
• Page End: 26
• Publication Date: 2013-02
• Subjects: Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.3109/13813455.2012.735245
• Languages: English
• ISSNs: 1381-3455

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Objectives:</italic> To assess the relationship of homocysteine, hs-CRP, with known cardiovascular risk factors of the metabolic syndrome.</p> <p> <italic>Method:</italic> Cross sectional study comprised 182 diabetic outpatients (70 males and 112 females), attending endocrinology clinics in Trinidad.</p> <p> <italic>Results:</italic> Both male and females showed significant linear relationships between high sensitive C-reactive protein (hs-CRP), blood pressure and diabetes (<italic>r</italic> = −0.2 &lt; <italic>R</italic> or <italic>R</italic> &gt; 0.2). In females hs-CRP showed significant linear relationship with HDL, triglyceride, blood pressure and diabetes mellitus (<italic>p</italic> &lt; 0.0001). The inverse relationship of hs-CRP with HDL implies the strong association of hs-CRP with metabolic syndrome. The multivariate logistic regression analysis showed significant relation of hs-CRP, metabolic syndrome and diabetes mellitus. There was no significant relationship of tHCY to any of the features studied.</p> <p> <italic>Conclusion:</italic> Serum C-reactive protein is significantly related to features of the metabolic syndrome. Total plasma homocysteine, appears to be independent of both hs-CRP and features of the metabolic syndrome.</p> </abstract>