CTLA-4 -1722T/C Polymorphism and Systemic Lupus Erythematosus Susceptibility: A Meta-analysis Involving Ten Separate Studies. (February 2013)

• Record Type: Journal Article
• Authors: Zhu, Ji-Min; Li, Bai-Kun; Chen, Gui-Mei; Feng, Chen-Chen; Cen, Han; Fan, Yin-Guang; Wang, Bin; Pan, Hai-Feng; Ye, Dong-Qing
• Is Part Of: Immunological investigations. Volume 42:Number 2(2013)
• Page Start: 91
• Page End: 105
• Publication Date: 2013-02
• Subjects: Immunology -- Periodicals; Immunochemistry -- Periodicals; Cellular immunity -- Periodicals; Communicable diseases -- Periodicals; 616.079
• DOI: 10.3109/08820139.2012.724752
• Languages: English
• ISSNs: 0882-0139

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Cytotoxic T lymphocyte associated antigen-4 (CTLA-4) -1722T/C polymorphism has been identified as a susceptibile gene for systemic lupus erythematosus (SLE), but studies are inconsistent. To better assess the association between CTLA-4 -1722T/C polymorphism and SLE, a meta-analysis was performed, including 10 studies, total of 1 387 patients and 1 617 controls. Overall, the CTLA-4 -1722T/C polymorphism was significantly associated with SLE susceptibility (T VS C: <italic>OR</italic> = 1.17, 95% <italic>CI</italic> = 0.86–1.60, <italic>P</italic> = 0.304; T/T VS C/C: <italic>OR</italic> = 1.92, 95% <italic>CI</italic> = 1.09–3.39, <italic>P</italic> = 0.024; T/C VS C/C: <italic>OR</italic> = 1.50, 95% <italic>CI</italic> = 0.91–2.49, <italic>P</italic> = 0.114; T/T VS T/C: <italic>OR</italic> = 1.29, 95% <italic>CI</italic> = 0.95–1.75, <italic>P</italic> = 0.107). When stratified by ethnicity, the CTLA-4 -1722T/C polymorphism was associated with SLE only in Asians (T VS C: <italic>OR</italic> = 1.47, 95% <italic>CI</italic> = 1.10–1.96, <italic>P</italic> = 0.010; T/T VS C/C: <italic>OR</italic> = 2.09, 95% <italic>CI</italic> = 1.13–3.85, <italic>P</italic> = 0.018; T/C VS C/C: <italic>OR</italic> = 1.53, 95% CI = 0.87–2.69, <italic>P</italic> = 0.141; T/T VS T/C: <italic>OR</italic> = 1.42, 95% CI = 0.97–2.09, <italic>P</italic> = 0.070). In summary, the CTLA-4 -1722T/C polymorphism confers to SLE risk, especially in Asians.</p> </abstract>