Can Dialysis Modality Influence Quality of Life in Chronic Hemodialysis Patients? Low-Flux Hemodialysis versus High-Flux Hemodiafiltration: A Cross-Over Study. (March 2013)

• Record Type: Journal Article
• Authors: Kantartzi, Konstantia; Panagoutsos, Stelios; Mourvati, Efthemia; Roumeliotis, Athanasios; Leivaditis, Konstantinos; Devetzis, Vassilios; Passadakis, Ploumis; Vargemezis, Vassilios
• Is Part Of: Renal failure. Volume 35:Number 2(2013)
• Page Start: 216
• Page End: 221
• Publication Date: 2013-03
• Subjects: Chronic renal failure -- Periodicals; Acute renal failure -- Periodicals; Uremia -- Periodicals; 616.614005
• DOI: 10.3109/0886022X.2012.743858
• Languages: English
• ISSNs: 0886-022X

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Background</italic>: Hemodiafiltration with online preparation of the substitution [online high-flux hemodiafiltration (OHDF)] and hemodiafiltration with prepared bags of substitution (HDF) are important, recently widely used renal replacement therapies in patients with end-stage renal disease. However, there is little information on the comparative impacts of these modalities versus conventional low-flux hemodialysis (HD) on the quality of life (QoL) of HD patients. This study investigates the effect of dialysis modality on QoL in chronic HD patients. <italic>Methods</italic>: In this prospective, randomized, cross-over, open label study, 24 patients were enrolled. Their age were 62 ± 13.34 years (mean ± SD), with the duration of dialysis of 31 ± 23.28 months (mean ± SD). Five of the patients were women. QoL was measured by the Short-Form Health Survey with 36 questions (SF-36) and subscale scores were calculated. Each patient received HD, OHDF, and HDF for 3 months, with the dialysis modality subsequently being altered. They completed the questionnaire of QoL at the end of each period. <italic>Results</italic>: There were statistical significant differences in QoL for the total SF-36 [36.1 (26.7–45.7) and 40.7 (30.2–62.8)], for classic low-flux HD and high-flux hemodiafiltration, for bodily pain [45 (26.9–66.9) and 55 (35.6–87.5)], and for role limitations due to emotional functioning [0 (0–33.3) and 33.3 (0–100)], respectively. The scores did not differ significantly between the two types of hemodiafiltration. <italic>Conclusions</italic>: Our study indicates that QoL differs significantly among patients receiving low-flux HD and high-flux hemodiafiltration, on total SF-36, bodily pain, and role limitations due to emotional functioning. Convective modalities may offer better QoL than diffusive HD.</p> </abstract>