Toxicity of the mycotoxin ochratoxin A in the light of recent data. (May 2013)

• Record Type: Journal Article
• Authors: Malir, Frantisek; Ostry, Vladimir; Novotna, Eva
• Is Part Of: Toxin reviews. Volume 32:Number 2(2013)
• Page Start: 19
• Page End: 33
• Publication Date: 2013-05
• Subjects: Toxicology -- Periodicals; Toxins -- Periodicals; 615.905
• DOI: 10.3109/15569543.2013.782504
• Languages: English
• ISSNs: 1556-9543

Abstract

<abstract> <title>Abstract</title> <p>Ochratoxin A (OTA) is a ubiquitous, naturally occurring chlorophenolic mycotoxin produced in contaminated food and feed by fungi of genera <italic>Penicillium</italic> and <italic>Aspergillus</italic>. OTA is a common contaminant of various foodstuffs of both plant and animal origin. OTA represents significant risk to human and animal health. OTA has been shown to be nephrotoxic, hepatotoxic, teratogenic, immunotoxic, neurotoxic, genotoxic and carcinogenic (possible human carcinogen-group 2B), being characterized by species and sex differences in sensitivity. In some aspects OTA remains as a controversial topic. Its metabolism, genotoxicity and mechanism of action for renal carcinogenicity have been discussed.</p> </abstract>