A Prospective Study of Percutaneous Vertebroplasty for Chronic Painful Osteoporotic Spinal Fractures. Issue 1 (March 2013)

• Record Type: Journal Article
• Authors: Zheng, Ruo-Kun; Wang, Yi-Sheng; Li, Jia-Zhen; Hao, Ying-Jie; Tan, Hong-Yu
• Is Part Of: Journal of musculoskeletal pain. Volume 21:Issue 1(2013)
• Page Start: 46
• Page End: 52
• Publication Date: 2013-03
• Subjects: Nonarticular rheumatism -- Periodicals; Myalgia -- Periodicals; Pain -- Periodicals; Musculoskeletal system -- Diseases -- Periodicals; 616.7
• DOI: 10.3109/10582452.2012.762819
• Languages: English
• ISSNs: 1058-2452

Abstract

<abstract abstract-type="executive-summary"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Objectives</title> <p>To evaluate the efficacy of percutaneous vertebroplasty [PV] in patients with chronic painful osteoporotic compression fractures.</p> </sec> <sec> <title>Methods</title> <p>We performed a prospective study in which participants with unhealed, painful chronic osteoporotic vertebral fractures for at least three months [low signal in T1 and high signal in T2 on magnetic resonance imaging [MRI]], as confirmed by MRI, were prospectively assigned to undergo PV or a conservative treatment [CT]. The primary outcome was pain relief at one week, one month, three months, six months, and one year, as measured by Visual Analog Scale score.</p> </sec> <sec> <title>Results</title> <p>A total of 40 participants were enrolled and 36 [19 of 20 in the PV group and 17 of 20 in the CT group] completed the one-year follow-up [90 percent]. Changes in mean VAS score between baseline and one month was –3.7 after PV and –2.4 after CT; between baseline and six months was –3.9 after PV and –2.4 after CT; and between baseline and one year was –4.0 after PV and –2.3 after CT. The difference between groups in the reduction of mean VAS score from baseline was 1.3 [P = 0.001] at one week, 1.5 [P = 0.001] at one month, and 1.6 [P < 0.001] at one year.</p> </sec> <sec> <title>Conclusion</title> <p>PV reduced pain more effectively than did CT. It is effective in a subgroup of patients with chronic osteoporotic vertebral fracture and persistent pain. Pain relief after PV is immediate and is sustained for one year.</p> </sec> </abstract>