Serum Fetuin-A Levels, QT Dispersion and P Dispersion in Dialysis Patients. (May 2013)

• Record Type: Journal Article
• Authors: Taskapan, Mehmet Cagatay; Taskapan, Hulya; Comert, Melda; Temel, Ismail; Yagmur, Julide; Ulutas, Ozkan
• Is Part Of: Renal failure. Volume 35:Number 4(2013)
• Page Start: 477
• Page End: 482
• Publication Date: 2013-05
• Subjects: Chronic renal failure -- Periodicals; Acute renal failure -- Periodicals; Uremia -- Periodicals; 616.614005
• DOI: 10.3109/0886022X.2013.768938
• Languages: English
• ISSNs: 0886-022X

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Background</italic>: This study aims to find association of fetuin-A with serum lipids, QT dispersion (QT-d), and P dispersion (P-d) in dialysis patients. <italic>Methods</italic>: Fetuin-A serum levels were assessed in 50 dialysis patients. <italic>Results</italic>: Serum fetuin-A levels were significantly associated with QT-d (<italic>r </italic>= 0.289, <italic>p</italic> = 0.044), P-d (<italic>r </italic>= 0.39, <italic>p</italic> = 0.005), total cholesterol (<italic>r </italic>= 0.526, <italic>p</italic> = 0.000), low-density lipoprotein cholesterol (LDL-C) (<italic>r </italic>= 0.456, <italic>p</italic> = 0.00), triglyceride (<italic>r </italic>= 0.360, <italic>p</italic> = 0.011) and highly sensitive C-reactive protein (hsCRP) (<italic>r </italic>= −0.347, <italic>p</italic> = 0.030). In step-wise multiple regression analysis including being on hemodialysis (HD), presence of diabetes mellitus (DM), total cholesterol, LDL-C, triglycerides, hsCRP, only total cholesterol (<italic>b </italic>= 0.419, <italic>p</italic> = 0.03), and hsCRP (<italic>b </italic>= −0.316, <italic>p</italic> = 0.03) proved to be independent predictors of serum fetuin-A levels. QT-d showed a linear correlation with total cholesterol (<italic>r </italic>= 0.309, <italic>p</italic> = 0.029), LDL-C (<italic>r </italic>= 0.304, <italic>p</italic> = 0.038), P-d (<italic>r </italic>= 0.390, <italic>p</italic> = 0.005), and fetuin-A levels (<italic>r </italic>= 0.289, <italic>p</italic> = 0.044). In multiple regression analyses, the independent predictor of QT-d was being on HD (<italic>b </italic>= −0.417, <italic>p</italic> = 0.004), whereas total cholesterol, LDL-C, presence of DM, serum fetuin-A levels, and P-d had no independent effect on corrected QT (QT-C). Being on HD and age were important determinants of P-d whereas presence of DM, total cholesterol, LDL-C, fetuin-A, and QT-d had no independent effect on P-d. <italic>Conclusions</italic>: Lower fetuin-A levels are associated with high hsCRP and low cholesterol levels in dialysis patients.</p> </abstract>