Association of Antithrombin Activity with Plasma Aldosterone Concentration and Plasma Renin Activity in Pregnant Women. (February 2013)

• Record Type: Journal Article
• Authors: Yamada, Takashi; Koyama, Takahiro; Furuta, Itsuko; Morikawa, Mamoru; Yamada, Takahiro; Minakami, Hisanori
• Is Part Of: Hypertension in pregnancy. Volume 32:Number 1(2013)
• Page Start: 96
• Page End: 103
• Publication Date: 2013-02
• Subjects: Hypertension in pregnancy -- Periodicals; Pregnancy -- Complications -- Periodicals; 618.3261
• DOI: 10.3109/10641955.2012.751995
• Languages: English
• ISSNs: 1064-1955

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Objective</italic>. To test the hypothesis that the blood antithrombin (AT) activity is correlated with the plasma aldosterone concentration (PAC), the plasma renin activity (PRA), and/or the PAC-to-PRA ratio during the late stage of pregnancy. <italic>Methods</italic>. The AT activity, PAC, and PRA were determined within 7 days prior to delivery in 47 women, consisting of 30 normotensive and 6 hypertensive women with singleton pregnancies and 11 normotensive women with twin pregnancies. <italic>Results</italic>. The median values of the 47 women were 86% of the normal activity level for the AT activity, 442 pg/mL for the PAC, 3.7 ng/mL/h for the PRA, and 108 pg/mL per ng/mL/h for the PAC-to-PRA ratio. Women with an AT activity ≤86% had a significantly lower PRA and a higher PAC-to-PRA ratio than women with an AT activity &gt;86% (3.5 ± 3.0 vs. 6.6 ± 4.7 ng/mL/h for PRA, <italic>p </italic>= 0.008; 156 ± 109 vs. 97 ± 46 pg/mL per ng/h for PAC-to-PRA ratio, <italic>p </italic>= 0.021). The AT activity was significantly correlated positively with the PRA and negatively with the PAC-to-PRA ratio. <italic>Conclusions</italic>. The existence of a common pathophysiological background between a reduced AT activity and a reduced PRA during the late stage of pregnancy was suggested.</p> </abstract>