Alterations in Mitochondrial Membrane in Chemopreventive Action of Fish Oil. (1st May 2013)

• Record Type: Journal Article
• Authors: Sharma, Gayatri; Rani, Isha; Kansal, Shevali; Bhatnagar, Archana; Agnihotri, Navneet
• Is Part Of: Cancer investigation. Volume 31:Number 4(2013)
• Page Start: 231
• Page End: 240
• Publication Date: 2013-05-01
• Subjects: Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.3109/07357907.2013.780076
• Languages: English
• ISSNs: 0735-7907

Abstract

<abstract> <title>ABSTRACT</title> <p>Mitochondria are major regulators of pathways related to tumorigenesis; therefore, mitochondrial membrane characteristics and associated cell signaling events were evaluated with different ratios of fish oil (FO) and corn oil (CO) in experimental colon carcinogenesis. Treatment with carcinogen 1, 2-dimethylhydrazine (DMH) altered reactive oxygen species (ROS), Ca²⁺, and membrane characteristics, which resulted in an elevation in apoptosis in initiation phase and reduction in post-initiation phase. FO+CO(2.5:1)+DMH treatment, however, altered mitochondrial membrane parameters, ROS, and Ca²⁺ to increase apoptosis in both phases, whereas FO+CO(1:1)+DMH treatment enhanced apoptosis only in post-initiation phase suggesting that FO supplementation in higher ratio has better chemopreventive efficacy.</p> </abstract>