Curcumin-containing chitosan nanoparticles as a potential mucoadhesive delivery system to the colon. (June 2013)

• Record Type: Journal Article
• Authors: Chuah, Lay Hong; Billa, Nashiru; Roberts, Clive J.; Burley, Jonathan C.; Manickam, Sivakumar
• Is Part Of: Pharmaceutical development and technology. Volume 18:Number 3(2013)
• Page Start: 591
• Page End: 599
• Publication Date: 2013-06
• Subjects: Drug delivery systems -- Periodicals; Pharmaceutical technology -- Periodicals; Drugs -- Administration -- Research -- Periodicals; Drug Delivery Systems -- Periodicals; Pharmaceutical Preparations -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615
• DOI: 10.3109/10837450.2011.640688
• Languages: English
• ISSNs: 1083-7450

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>In the present study, we investigate the mucoadhesive characteristics and release of the anticancer agent curcumin, contained in chitosan nanoparticles (CS-NPs). Such a system has potential therapeutic benefits in the treatment of colon cancer through prolonged retention and delivery. The CS-NPs were ionically gelled with tripolyphosphate (TPP) and registered an isoelectric pH of 6.2 (z-average diameter of 214 nm ± 1.0 nm). pH variations around the isoelectric point caused a reduction in CS-NPs electrical charge which correspondingly increased the z-average due to agglomeration. Curcumin release from CS-NPs was slowest at chitosan to TPP weight ratio of 3:1, with a significant retention (36%) at the end of 6 h. Adsorption isotherms of mucin on CS-NPs fitted both the Freundlich and Langmuir models, suggesting a monolayer-limited adsorption on heterogeneous sites with varied affinities. Encapsulated curcumin exerted an influence on the adsorption of mucin due to H-bonding as well as π-π interactions between the phenolic moieties of curcumin and mucin.</p> </abstract>