Vascular Effects of Aqueous Extract of Chamaemelum nobile : In Vitro Pharmacological Studies in Rats. (May 2013)

• Record Type: Journal Article
• Authors: Zeggwagh, Naoufel Ali; Michel, Jean Baptiste; Eddouks, Mohamed
• Is Part Of: Clinical and experimental hypertension. Volume 35:Number 3(2013)
• Page Start: 200
• Page End: 206
• Publication Date: 2013-05
• Subjects: Hypertension -- Chemotherapy -- Periodicals; Hypotensive agents -- Periodicals; 616.132
• DOI: 10.3109/10641963.2012.712179
• Languages: English
• ISSNs: 1064-1963

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>This study aims to evaluate the <italic>in vitro</italic> vasorelaxant effect of <italic>C. nobile</italic> aqueous extract. We use aortic ring isolated from Wistar rats and aqueous <italic>C. nobile</italic> extract at doses of 5, 10 and 20 mg/ml. Incubation of aqueous <italic>C. nobile</italic> extract for 30 minutes produced a significant shift of the dose–response curve to norepinephrine (NE) (10^–8 to 10^–5 M) (<italic>p</italic> &lt; 0.001). This study demonstrates that aqueous <italic>C. nobile</italic> extract possesses <italic>in vitro</italic> vasorelaxant effect.</p> </abstract>