Weight Loss in Obese Prepubertal Children: The Influence of Insulin Resistance. (July 2013)

• Record Type: Journal Article
• Authors: Chiavaroli, Valentina; Giannini, Cosimo; D'Adamo, Ebe; de Giorgis, Tommaso; Torello, Monica; D'Orazio, Nicolantonio; Sestili, Simona; Chiarelli, Francesco; Mohn, Angelika
• Is Part Of: Endocrine research. Volume 38:Number 1(2013:Feb.)
• Page Start: 48
• Page End: 57
• Publication Date: 2013-07
• Subjects: Endocrinology, Experimental -- Periodicals; Endocrinology -- Periodicals; Endocrinology -- Periodicals; Research -- Periodicals; 616.4
• DOI: 10.3109/07435800.2012.713424
• Languages: English
• ISSNs: 0743-5800

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Background</italic>. Insulin resistance (IR), a link of paramount importance between obesity and cardiovascular/metabolic complications, seems to be implicated in weight changes. <italic>Objective</italic>. To determine whether IR could influence weight status during a 1-year intervention program in obese prepubertal children. <italic>Methods</italic>. Forty-four children with IR (IR group) and 42 children without IR (NIR group) were enrolled. Body mass index standard deviation score (BMI-SDS), waist circumference (WC), and homeostasis model assessment (HOMA-IR) were evaluated. <italic>Results</italic>. NIR children showed a significant reduction of BMI-SDS and WC at final assessment (<italic>p</italic> = 0.009 and <italic>p</italic> = 0.001, respectively), whereas IR children presented unchanged values. HOMA-IR decreased after intervention in the NIR group (<italic>p</italic> = 0.0008), but was exacerbated in IR children (<italic>p</italic> = 0.004). A positive and significant association between HOMA-IR at baseline and BMI at follow-up was found (<italic>B</italic> ± SE = 0.87 ± 0.24, <italic>p</italic> = 0.001). HOMA-IR at baseline was also significantly associated with WC at follow-up (<italic>B</italic> ± SE = 2.12 ± 0.69, <italic>p</italic> = 0.003). <italic>Conclusions</italic>. IR seems to influence adiposity changes in obese prepubertal children. Further longitudinal studies are needed to verify the relationship between IR and weight loss during childhood.</p> </abstract>