Usefulness of OCT4/3 Immunostain in Pediatric Malignant Germ Cell Tumors. (13th March 2013)

• Record Type: Journal Article
• Authors: Talebagha, Sarah; Rizk, Christine; Elawabdeh, Nancy; Abramowsky, Carlos R.; Shehata, Bahig M.
• Is Part Of: Fetal and pediatric pathology. Volume 32:Number 2(2013)
• Page Start: 82
• Page End: 87
• Publication Date: 2013-03-13
• Subjects: Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.3109/15513815.2012.671448
• Languages: English
• ISSNs: 1551-3815

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Octamer4/3 is a POU transcription factor that regulates pluripotentiality in embryonic stem and germ cells and primordial germ cells. When expressed in post-embryonic life, Octamer4/3 may lead to malignant germ cell tumors (GCT). Thirty samples were selected for this study (26 GCT samples and 4 cryptorchid testes samples) and 16 non-GCT were used as controls. Samples were stained with an anti-Octamer4/3 antibody. All cases of GCT were positive for Octamer4/3, and the non-GCT were negative. This article focuses on pediatric populations where we found that Octamer4/3 immunostaining is a useful diagnostic tool in undifferentiated pediatric tumors.</p> </abstract>