Effects of parental and household smoking on the risk of respiratory syncytial virus (RSV) hospitalisation in late-preterm infants and the potential impact of RSV prophylaxis. (June 2013)

• Record Type: Journal Article
• Authors: Carbonell-Estrany, Xavier; Fullarton, John R.; Gooch, Katherine L.; Vo, Pamela G.; Figueras-Aloy, Jose; Lanari, Marcello; Gouyon, Jean-Bernard; Liese, Johannes G.
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 26:Number 9(2013:Sep.)
• Page Start: 926
• Page End: 931
• Publication Date: 2013-06
• Subjects: Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2013.765850
• Languages: English
• ISSNs: 1476-7058

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: To assess the impact of household smoking and palivizumab prophylaxis on the risk of respiratory syncytial virus (RSV) hospitalisation in late-preterm (32–35 weeks' gestational age) infants.</p> <p> <italic>Methods</italic>: Familial smoking and other RSV risk factor data from the FLIP, FLIP-2 and IMpact studies and datasets from France, Germany and Italy, together with palivizumab prophylaxis data from the FLIP-2 and IMpact studies, were analysed using cross-correlation and Bayesian meta-analytical modelling employing Markov Chain Monte Carlo sampling.</p> <p> <italic>Results</italic>: There were 2.35 times (95% confidence interval [CI] 1.37–4.02) as many hospitalisations amongst infants from smoking compared with those from non-smoking families. Among non-prophylaxed infants, there were 2.53 times (95% CI 1.27–4.94) as many RSV hospitalisations from smoking than from non-smoking families and that excess hospitalisation was reduced to 1.03 times (95% CI 0.38–2.99) amongst prophylaxed infants. Familial smoking correlates significantly (<italic>p</italic> < 0.01) with other RSV risk factors: positive correlation with number of school-age siblings, history of family atopy, family wheeze and gestational age; negative correlation with birth weight and breast feeding.</p> <p> <italic>Conclusions</italic>: Late-preterm infants from smoking families appear to be at heightened risk for severe RSV infection requiring hospitalisation of which the risk may be reduced with RSV prophylaxis.</p> </abstract>