Anti-Müllerian hormone and polycystic ovary syndrome: assessment of the clinical pregnancy rates in in vitro fertilization patients. (May 2013)

• Record Type: Journal Article
• Authors: Sahmay, Sezai; Guralp, Onur; Aydogan, Begum; Cepni, Ismail; Oral, Engin; Irez, Tulay
• Is Part Of: Gynecological endocrinology. Volume 29:Number 5(2013:May)
• Page Start: 440
• Page End: 443
• Publication Date: 2013-05
• Subjects: Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.3109/09513590.2013.769519
• Languages: English
• ISSNs: 0951-3590

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: The purpose of this study is to investigate the role of serum anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH) and antral follicle count (AFC) for the prediction of clinical pregnancy rates (CPR) in women with polycystic ovary syndrome (PCOS) undergoing IVF treatment.</p> <p> <italic>Design</italic>: Prospective cohort study.</p> <p> <italic>Setting</italic>: University hospital.</p> <p> <italic>Patients</italic>: One hundred and fifty consecutive women with PCOS.</p> <p> <italic>Interventions</italic>: All women underwent controlled ovarian stimulation with long agonist protocol followed by IVF procedure. Outcomes of pregnant and non-pregnant groups were compared.</p> <p> <italic>Main outcome measure</italic>: CPR; AMH, FSH and AFC means and percentiles.</p> <p> <italic>Results</italic>: Fifty-one (34%) clinical pregnancies were observed in 150 women. Mean AMH was 6.7 ± 2.8 and 7.1 ± 4.3 ng/mL in pregnant and non-pregnant women, respectively (<italic>p</italic> = 0.594). The CPR were 27.8%, 35.0% and 37.8% in <25%, 25%–75% and >75% AMH percentiles, respectively (<italic>p</italic> = 0.656). There were also no significant difference in mean FSH and AFC between pregnant and non-pregnant women (<italic>p </italic>= 0.484 and <italic>p </italic>= 0.165, respectively).</p> <p> <italic>Conclusion</italic>: AMH, FSH and AFC are not predictive for CPR in women with PCOS undergoing IVF treatment. Mean AMH values were not significantly different between pregnant and non-pregnant women. Although CRP increased in parallel with the raise in AMH percentiles, this remained insignificant.</p> </abstract>