Left atrial volume index as a marker of left ventricular diastolic dysfunction in asymptomatic Tanzanian diabetic patients. (April 2013)

• Record Type: Journal Article
• Authors: Chillo, Pilly; Rieck, Åshild E.; Lwakatare, Johnson; Lutale, Janet; Gerdts, Eva
• Is Part Of: Blood pressure. Volume 22:Number 2(2013)
• Page Start: 86
• Page End: 93
• Publication Date: 2013-04
• Subjects: Blood pressure -- Periodicals; Hypertension -- Periodicals; Hypertension -- Periodicals; Blood Pressure -- Periodicals; 612.14
• DOI: 10.3109/08037051.2012.707351
• Languages: English
• ISSNs: 0803-7051

Abstract

<abstract> <title>Abstract</title> <p> <italic>Aim:</italic> To determine the prevalence of left atrial (LA) enlargement and its relation to left ventricular (LV) diastolic dysfunction among asymptomatic diabetic outpatients attending Muhimbili National Hospital in Dar es Salaam, Tanzania. <italic>Methods:</italic> Echocardiography was performed in 122 type 2 and 58 type 1 diabetic patients. Diastolic dysfunction was defined as peak transmitral blood velocity to medial mitral annulus velocity (E/E') ratio ≥ 15. LA volume indexed to body surface area (LAVI) was considered enlarged if ≥ 29 ml/m². <italic>Results:</italic> Enlarged LAVI and LV diastolic dysfunction were more common in type 2 than in type 1 diabetic patients (44.3 vs 25.9% and 20.5 vs 3.5%, respectively, both <italic>p</italic> &lt; 0.05). In multivariate linear regression analysis, larger LAVI was associated with LV diastolic dysfunction independent of significant associations with LV mass index and presence of mitral regurgitation in type 2 diabetic patients, while LV mass index, lower ejection fraction and longer duration of diabetes were the main covariates of larger LAVI in type 1 diabetic patients (all <italic>p</italic> &lt; 0.05). <italic>Conclusion:</italic> Enlarged LA is common among asymptomatic Tanzanian diabetic patients, and particularly associated with LV diastolic dysfunction in type 2, and with cardiomyopathy and lower systolic function in type 1 diabetic patients.</p> </abstract>