Mechanobiology in cardiac physiology and diseases. Issue 2 (27th February 2013)

• Record Type: Journal Article
• Authors: Takahashi, Ken; Kakimoto, Yoshihide; Toda, Kensaku; Naruse, Keiji
• Is Part Of: Journal of cellular and molecular medicine. Volume 17:Issue 2(2013)
• Page Start: 225
• Page End: 232
• Publication Date: 2013-02-27
• Subjects: Cytology; Medicine; Molecular Biology; Cytologie -- Périodiques; Médecine -- Périodiques; Biologie moléculaire -- Périodiques; Cytology -- Periodicals; Medicine -- Periodicals; Molecular biology -- Periodicals; 611.01805
• DOI: 10.1111/jcmm.12027
• Languages: English
• ISSNs: 1582-1838

Abstract

<abstract abstract-type="main" xml:lang="en" id="jcmm12027-abs-0001"> <title>Abstract</title> <p>Mechanosensitivity is essential for heart function just as for all other cells and organs in the body, and it is involved in both normal physiology and diseases processes of the cardiovascular system. In this review, we have outlined the relationship between mechanosensitivity and heart physiology, including the Frank–Starling law of the heart and mechanoelectric feedback. We then focused on molecules involved in mechanotransduction, particularly mechanosensitive ion channels. We have also discussed the involvement of mechanosensitivity in heart diseases, such as arrhythmias, hypertrophy and ischaemic heart disease. Finally, mechanobiology in cardiogenesis is described with regard to regenerative medicine.</p> </abstract>