Changes in endoscopic findings of gastritis after cure of H. pylori infection: Multicenter prospective trial. Issue 3 (8th November 2012)

• Record Type: Journal Article
• Authors: Kato, Mototsugu; Terao, Shuichi; Adachi, Kyoichi; Nakajima, Shigemi; Ando, Takashi; Yoshida, Norimasa; Uedo, Noriya; Murakami, Kazunari; Ohara, Shuichi; Ito, Masanori; Uemura, Naomi; Shimbo, Takuro; Watanabe, Hidenobu; Kato, Takahiro; Ida, Kazunori
• Is Part Of: Digestive endoscopy. Volume 25:Issue 3(2013:May)
• Page Start: 264
• Page End: 273
• Publication Date: 2012-11-08
• Subjects: Digestive organs -- Diseases -- Periodicals; Digestive organs -- Diseases -- Diagnosis -- Periodicals; Endoscopy -- Periodicals; Digestive System Diseases -- diagnosis -- Periodicals; Digestive System Diseases -- therapy -- Periodicals; Endoscopy -- Periodicals; 616.3
• DOI: 10.1111/j.1443-1661.2012.01385.x
• Languages: English
• ISSNs: 0915-5635

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="den1385-sec-0001" sec-type="section"> <title>Background and Aim</title> <p>Successful eradication of <italic>H. pylori</italic> changes pathological findings of gastritis dramatically. However, change of endoscopic mucosal findings is not fully understood. To clarify the short‐term changes of endoscopic mucosal findings after cure of <italic>H. pylori</italic> infection, a multicenter prospective trial was conducted.</p> </sec> <sec id="den1385-sec-0002" sec-type="section"> <title>Methods</title> <p>One hundred and forty‐seven patients with <italic>H. pylori</italic> infection from 12 institutions were enrolled into this prospective cohort trial. Nineteen endoscopic findings using high‐resolution white light electronic endoscopy were assessed before and 2–4 months after eradication treatment of <italic>H. pylori</italic>. <italic>H. pylori</italic> infection was diagnosed by pathology of three stomach sites using hematoxylin‐eosin stain or <italic>H. pylori</italic>‐specific immunostaining. Endoscopic features of the successful eradication group and the failed eradication group were compared. The change of severity of endoscopic features before and after <italic>H. pylori</italic> eradication were compared between successful eradication and failed eradication.</p> </sec> <sec id="den1385-sec-0003" sec-type="section"> <title>Results</title> <p>One hundred and twenty‐six patients were analyzed. Eradication rate was 81% (102/126). Non‐transparency of gastric juice, diffuse redness of fundic mucosa, enlarged fold, spotty redness of fundic mucosa, flat erosion of stomach, and hemoglobin index of fundic mucosa were significantly different between the successful eradication group and the failed eradication group. Gastric flat erosion was of higher frequency in the successful eradication group. When eradication was successful, spotty redness of fundic gland improved significantly.</p> </sec> <sec id="den1385-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Assessment of endoscopic findings of spotty redness after eradication treatment is useful in the diagnosis of <italic>H. pylori</italic> eradication.</p> </sec> </abstract>