C‐reactive protein and incidence of type 2 diabetes in the Pizarra study. (20th December 2012)

• Record Type: Journal Article
• Authors: Rubio‐Martín, Elehazara; Soriguer, Federico; Gutiérrez‐Repiso, Carolina; Garrido‐Sánchez, Lourdes; de, Marisol S. Ruíz; García‐Fuentes, Eduardo; Morcillo, Sonsoles; Esteva, Isabel; Chaves, Felipe J; Rojo‐Martinez, Gemma
• Is Part Of: European journal of clinical investigation. Volume 43:Number 2(2013:Feb.)
• Page Start: 159
• Page End: 167
• Publication Date: 2012-12-20
• Subjects: Pathology -- Periodicals; Medical research -- Periodicals; 616.075
• DOI: 10.1111/eci.12027
• Languages: English
• ISSNs: 0014-2972

Abstract

<abstract abstract-type="main" id="eci12027-abs-0001"> <title>Abstract</title> <sec id="eci12027-sec-0001" sec-type="section"> <title>Aim</title> <p>To determine the association between serum levels of high‐sensitivity C‐reactive protein (hs‐CRP) and the incidence of type 2 diabetes in a prospective cohort from southern Spain (Pizarra study).</p> </sec> <sec id="eci12027-sec-0002" sec-type="section"> <title>Materials and methods</title> <p>The study formed part of the Pizarra cohort study, a prospective study started in 1995 with a follow‐up of 11 years. Anthropometric and metabolic variables were measured at baseline and at 6 years and 11 years of follow‐up<bold>.</bold> All subjects underwent an oral glucose tolerance test. Serum levels of TNFα and its receptors, hs‐CRP, IL‐6, leptin, adiponectin and FABP4 were measured at 6 years of follow‐up.</p> </sec> <sec id="eci12027-sec-0003" sec-type="section"> <title>Results</title> <p>After adjusting for age, sex and obesity, subjects with levels of hs‐CRP> 2.9 mg/L in the second study (2003–4) had a higher risk of developing type 2 diabetes by the third study (2008–9) (OR = 7.97; 95% CI = 1.72–36.89; <italic>P</italic> = 0.008), and subjects with adiponectin levels > 13.2 mg/L had a lower risk of developing type 2 diabetes (OR = 0.23, <italic>P</italic> = 0.02). High values of hs‐CRP and high values of adiponectin were associated positively (OR = 8.26; 95% CI = 1.84–37.19; <italic>P</italic> = 0.006) and negatively (OR = 0.17; 95% CI = 0.04–0.69; <italic>P</italic> = 0.01), respectively, with the risk of having HbA1c ≥ 6.5% at 11 years of follow‐up.</p> </sec> <sec id="eci12027-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Subjects with high serum hs‐CRP levels and low serum adiponectin levels have a higher risk of developing type 2 diabetes within five years.</p> </sec> </abstract>