Mesotherapy using dutasteride‐containing preparation in treatment of female pattern hair loss: photographic, morphometric and ultrustructural evaluation. (6th April 2012)

• Record Type: Journal Article
• Authors: Moftah, N.; Moftah, N.; Abd‐Elaziz, G.; Ahmed, N.; Hamed, Y.; Ghannam, B.; Ibrahim, M.
• Is Part Of: Journal of the European Academy of Dermatology and Venereology. Volume 27:Number 6(2013:Jun.)
• Page Start: 686
• Page End: 693
• Publication Date: 2012-04-06
• Subjects: Dermatology -- Periodicals; Sexually transmitted diseases -- Periodicals; 616.5
• DOI: 10.1111/j.1468-3083.2012.04535.x
• Languages: English
• ISSNs: 0926-9959

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p> <bold>Background </bold> Treatment of female pattern hair loss (FPHL) is frustrating for both patients and doctors. Mesotherapy is a novel treatment for hair fall and its efficacy in FPHL has not been evaluated.</p> <p> <bold>Objective </bold> Evaluation of the efficacy and safety of mesotherapy using dutasteride‐containing preparation in treatment of FPHL.</p> <p> <bold>Methods </bold> This study included 126 female patients with FPHL. They were classified into two groups; group I (86 patients) injected with dutasteride‐containing preparation and group II (40 control patients) injected with saline. Patients received 12 sessions and were evaluated at the 18th week by: photographic assessment, hair pull test, hair diameter and patient self‐assessment. Ultrastructural evaluation was done for three patients.</p> <p> <bold>Results </bold> After mesotherapy with dutasteride‐containing preparation, photographic improvement occurred in 62.8% of patients compared with 17.5% in control group (<italic>P</italic> < 0.05), mean number of epilated hairs was significantly decreased (<italic>P</italic> < 0.05), mean hair diameter was significantly increased (<italic>P</italic> < 0.05). Patient self‐assessment showed statistically significant improvement compared with the controls (<italic>P</italic> < 0.05). There was a negative correlation between degree of improvement and duration of FPHL (<italic>P</italic> < 0.05). Side effects were minimal with no statistically significant difference between the two groups (<italic>P</italic> > 0.05). Ultrastructural examination of pretreated hairs revealed absent cuticle in one patient and focal destruction of the cuticle in the second patient, which reappeared in both after therapy.</p> <p> <bold>Conclusion </bold> We concluded that mesotherapy with dutasteride‐containing preparation was effective, tolerable and minimally invasive treatment modality in FPHL with better response for shorter duration of the disease.</p> </abstract>