The metabolic deterioration that antedates diabetes: personal trajectories of HbA1c and fasting glucose as early indicators and possible triggers for intervention. Issue 1 (8th January 2013)

• Record Type: Journal Article
• Authors: Dankner, Rachel; Bergman, Michael; Danoff, Ann; Qureshi, Sana; Whitford, Ian; Kaviani, Nargess; Dynkevich, Yevgeniya; Roth, Jesse
• Is Part Of: Diabetes/metabolism research and reviews. Volume 29:Issue 1(2013:Jan.)
• Page Start: 1
• Page End: 7
• Publication Date: 2013-01-08
• Subjects: Diabetes -- Periodicals; Metabolism -- Periodicals; 616.642
• DOI: 10.1002/dmrr.2373
• Languages: English
• ISSNs: 1520-7552

Abstract

<abstract abstract-type="main"> <title>Summary</title> <p>HbA_1c testing has become an accepted means of diagnosing diabetes as an alternative to blood glucose levels. However, population‐based norms of glucose and of HbA_1c levels do not enable the detection of diabetes at an early enough stage to thwart complications. Personal trajectories of glucose levels show steep increases a number of years prior to diabetes diagnosis. Here, we hypothesize that a comparable time‐dependent deviation in an individual's HbA_1c level may be an early manifestation of disease that should prompt lifestyle modifications. We predict that analysis of personal trajectories of glucose and of HbA_1c will promote earlier intervention and a greater reduction in disease complications than current standards, which are based on population‐based norms. Copyright © 2012 John Wiley &amp; Sons, Ltd.</p> </abstract>