Sleep‐Wake profiles in patients with primary biliary cirrhosis. (22nd November 2012)

• Record Type: Journal Article
• Authors: Montagnese, Sara; Nsemi, Letizia M.; Cazzagon, Nora; Facchini, Silvia; Costa, Laura; Bergasa, Nora V.; Amodio, Piero; Floreani, Annarosa
• Is Part Of: Liver international. Volume 33:Number 2(2013:Feb.)
• Page Start: 203
• Page End: 209
• Publication Date: 2012-11-22
• Subjects: Liver -- Periodicals; Liver -- Diseases -- Periodicals; 616.362
• DOI: 10.1111/liv.12026
• Languages: English
• ISSNs: 1478-3223

Abstract

<abstract abstract-type="main" id="liv12026-abs-0001"> <title>Abstract</title> <sec id="liv12026-sec-0001" sec-type="section"> <title>Background</title> <p>Impaired sleep quality and daytime sleepiness have been described in patients with primary biliary cirrhosis (PBC). However, no information is available on their sleep timing/diurnal preference.</p> </sec> <sec id="liv12026-sec-0002" sec-type="section"> <title>Aims</title> <p>To evaluate such variables and determine their relationship with sleep quality, fatigue, pruritus and quality of life.</p> </sec> <sec id="liv12026-sec-0003" sec-type="section"> <title>Methods</title> <p>Seventy‐four patients with PBC (58 ± 12 years), 79 healthy volunteers (56 ± 8 years) and 60 patients with cirrhosis (58 ± 12 years) underwent formal assessment of sleep quality/timing, diurnal preference and daytime sleepiness. Patients with PBC also underwent assessment of fatigue, quality of life and the daytime course of sleepiness/pruritus.</p> </sec> <sec id="liv12026-sec-0004" sec-type="section"> <title>Results</title> <p>Sleep timing was significantly delayed in both patients with PBC and with cirrhosis, compared to healthy volunteers (sleep onset time: 23:18 ± 01:00 vs. 23:30 ± 01:00 vs. 22:54 ± 00:54 hours, respectively; <italic>P</italic> < 0.05). In patients with PBC, delayed sleep timing was associated with impaired sleep quality (<italic>P</italic> < 0.05). Sleepiness showed a physiological daily rhythm, with early afternoon/evening peaks. Pruritus was absent in the morning and increased over the afternoon/evening hours. Both the daytime course of pruritus and sleepiness changed in relation to diurnal preference. Patients with PBC and significant pruritus (upper quartile) had prolonged sleep latency (39 ± 37 vs. 21 ± 23 min, <italic>P</italic> = 0.05) and earlier wake‐up times (5.9 ± 0.8 vs. 6.7 ± 0.9 min, <italic>P</italic> < 0.05). Significant correlations were observed between sleep timing and quality of life.</p> </sec> <sec id="liv12026-sec-0005" sec-type="section"> <title>Conclusions</title> <p>Patients with PBC exhibited a delay in sleep timing that was associated with impaired sleep quality/quality of life. In addition, an interplay was observed between diurnal preference and the daytime course of pruritus/sleepiness.</p> </sec> </abstract>