Sirolimus therapy may cause cardiac tamponade. (29th November 2012)

• Record Type: Journal Article
• Authors: Bertrand, Dominique; Desbuissons, Geoffroy; Pallet, Nicolas; Debure, Alain; Sartorius, Albane; Anglicheau, Dany; Mamzer, Marie‐France; Legendre, Christophe; Sberro‐Soussan, Rebecca
• Is Part Of: Transplant international. Volume 26:Number 2(2013:Feb.)
• Page Start: e4
• Page End: e7
• Publication Date: 2012-11-29
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; 617.95405
• DOI: 10.1111/tri.12025
• Languages: English
• ISSNs: 0934-0874

Abstract

<abstract abstract-type="main" id="tri12025-abs-0001"> <title>Summary</title> <p>The side‐effects associated with the immunosuppressive drug sirolimus are numerous and constitute a major limitation for its use in renal transplantation. In this study, we describe two cases of renal transplant recipients treated with sirolimus who developed pericardial tamponade associated with interstitial pneumonia, proteinuria, microcytic anemia and, in one case, lymphocytic meningitidis. An extensive search for infectious agents was negative, and all symptoms disappeared after sirolimus interruption. Therefore, this case demonstrates for the first time that sirolimus can cause pericardial tamponade as well as lymphocytic meningitidis.</p> </abstract>