Correlations between serum levels of beta amyloid, cerebrospinal levels of tau and phospho tau, and delayed response tasks in young and aged cynomolgus monkeys (Macaca fascicularis). Issue 3 (26th March 2013)

• Record Type: Journal Article
• Authors: Darusman, H.S.; Sajuthi, D.; Kalliokoski, O.; Jacobsen, K.R.; Call, J.; Schapiro, S.J.; Gjedde, A.; Abelson, K.S.P.; Hau, J.
• Is Part Of: Journal of medical primatology. Volume 42:Issue 3(2013)
• Page Start: 137
• Page End: 146
• Publication Date: 2013-03-26
• Subjects: Primates -- Periodicals; Primates -- Diseases -- Periodicals; Medicine, Experimental -- Periodicals; 616.02738
• DOI: 10.1111/jmp.12044
• Languages: English
• ISSNs: 0047-2565

Abstract

<abstract abstract-type="main" id="jmp12044-abs-0001"> <title>Abstract</title> <sec id="jmp12044-sec-0001" sec-type="section"> <title>Background</title> <p>In an attempt to explore cynomolgus monkeys as an animal model for Alzheimer's disease, the present study focused on the Alzheimer's biomarkers beta amyloid 1–42 (Aβ₄₂) in serum, and total tau (t‐tau) and phosphorylated tau (p‐tau) levels in cerebrospinal fluid.</p> </sec> <sec id="jmp12044-sec-0002" sec-type="section"> <title>Methods</title> <p>We measured biomarker levels in Young and Aged cynomolgus monkeys and correlated these with performance on three delayed response tasks.</p> </sec> <sec id="jmp12044-sec-0003" sec-type="section"> <title>Results</title> <p>The Aβ₄₂ concentration of the Aged monkeys was significantly lower than in the Young subjects, while the t‐tau and p‐tau did not significantly differ between the groups. The Young subjects performed significantly better than the Aged individuals on the memory tests. Only Aβ₄₂ levels were significantly correlated with performance in the three delayed response tasks.</p> </sec> <sec id="jmp12044-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Circulating Aβ₄₂ levels were lower in Aged monkeys and were correlated with inferior performance on delayed response tasks in Aged animals; therefore, both measures may be useful in establishing cynomolgus monkeys as models for studies of AD.</p> </sec> </abstract>