Pregnancy‐associated plasma protein‐A is related to gender and to adipocytokine levels: results of The Health Survey of Catalonia. (10th April 2013)

• Record Type: Journal Article
• Authors: Joaquín, Clara; Granada, Maria L.; Pastor, Cruz; Castell, Conxa; Puig, Rocío; Alonso, Núria; Serra, Enric; Sanmartí, Anna; Foz, Marius; Puig‐Domingo, Manel
• Is Part Of: Clinical endocrinology. Volume 78:Number 5(2013:May)
• Page Start: 718
• Page End: 723
• Publication Date: 2013-04-10
• Subjects: Endocrinology -- Periodicals; 616.4005
• DOI: 10.1111/j.1365-2265.2012.04469.x
• Languages: English
• ISSNs: 0300-0664

Abstract

<abstract abstract-type="main" id="cen4469-abs-0001"> <title>Summary</title> <sec id="cen4469-sec-0001" sec-type="section"> <title>Objective</title> <p>Pregnancy‐associated plasma protein‐A (PAPP‐A) is a protease promoting IGF1 tissue availability and considered as a new biomarker of cardiovascular disease.</p> </sec> <sec id="cen4469-sec-0002" sec-type="section"> <title>Aim</title> <p>To evaluate the relationship between PAPP‐A concentrations and anthropometric variables, physical activity, smoking status, glucose homoeostasis and adipocytokines in healthy adults.</p> </sec> <sec id="cen4469-sec-0003" sec-type="section"> <title>Design and methods</title> <p>One hundred and forty‐nine subjects (77 women; mean age 39·7 ± 14 years; mean BMI 23·7 ± 1·9 kg/m<sup>2</sup>) were randomly selected from 8000 adults of The Health Survey of Catalonia. Possible effects of gender, age, body composition, smoking status, physical activity, glucose homoeostasis and adipocytokines on PAPP‐A concentrations were assessed.</p> </sec> <sec id="cen4469-sec-0004" sec-type="section"> <title>Results</title> <p>Pregnancy‐associated plasma protein‐A was significantly higher in men than in women [ 1·04 (0·61–0·44) <italic>vs</italic> 0·61 (0·41–0·90) μIU/ml; <italic>P </italic><<italic> </italic>0·0001]; there were no differences in relation to physical activity or smoking status. PAPP‐A showed a negative correlation with leptin in men (<italic>P</italic> = 0·01) and women (<italic>P</italic> = 0·05), and a positive correlation with adiponectin (<italic>P</italic> = 0·006) in women and a trend (<italic>P</italic> = 0·073) in men. Homoeostasis model assessment of insulin resistance (HOMA‐IR) showed a negative correlation with PAPP‐A only in women (<italic>P</italic> = 0·019). No association was found with blood pressure, IGF1, lipids or glucose in either gender. When a multiple regression analysis was performed including gender, age, BMI, waist‐hip ratio, HOMA‐IR, adiponectin and leptin as confounders, PAPP‐A was independently correlated with adiponectin (β = 0·23; <italic>P</italic> = 0·02) and leptin (β = −0·33; <italic>P</italic> = 0·04).</p> </sec> <sec id="cen4469-sec-0005" sec-type="section"> <title>Conclusions</title> <p>Our study shows a sexual dimorphism of PAPP‐A, and a possible influence of leptin and adiponectin on its concentrations in healthy subjects. The mechanisms responsible for this relationship remain to be determined.</p> </sec> </abstract>