The Merkel Cell Polyomavirus and Its Involvement in Merkel Cell Carcinoma. Issue 2 (6th February 2013)

• Record Type: Journal Article
• Authors: Amber, Kyle; McLeod, Michael P.; Nouri, Keyvan
• Is Part Of: Dermatologic surgery. Volume 39:Issue 2(2013)
• Page Start: 232
• Page End: 238
• Publication Date: 2013-02-06
• Subjects: Skin -- Surgery -- Periodicals; Skin -- Diseases -- Surgery -- Periodicals; 617.477
• DOI: 10.1111/dsu.12079
• Languages: English
• ISSNs: 1076-0512

Abstract

<abstract abstract-type="main" xml:lang="en" id="dsu12079-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="dsu12079-sec-0001" sec-type="section"> <title>Background</title> <p>The discovery of the Merkel cell polyomavirus (MCV) in a large number of Merkel cell carcinomas (MCCs) has led to many investigations into its potential role as an oncovirus. Many studies have recently explored the differences between MCCs infected and not infected with MCV.</p> </sec> <sec id="dsu12079-sec-0002" sec-type="section"> <title>Objective</title> <p>To review the role of MCV in MCC and its potential to influence diagnosis, prognosis, and treatment.</p> </sec> <sec id="dsu12079-sec-0003" sec-type="section"> <title>Methods and Materials</title> <p>An extensive literature search was performed on MCV and its relationship with other polyomaviruses and MCC. The immune system's role in MCC was also investigated.</p> </sec> <sec id="dsu12079-sec-0004" sec-type="section"> <title>Results</title> <p>We included 60 articles regarding MCC and MCV and seven pertinent to general processes involved with MCC and MCV.</p> </sec> <sec id="dsu12079-sec-0005" sec-type="section"> <title>Conclusion</title> <p>Merkel cell polyomavirus appears to affect many aspects of MCC. An understanding of this virus may aid in future therapy options and current pathology protocols in diagnosing MCC. The host's immune function appears to affect MCV's ability to cause cellular transformation leading to MCC.</p> </sec> </abstract>