Anti‐inflammatory Activities of Eleven Centaurea Species Occurring in the Carpathian Basin. (4th June 2012)

• Record Type: Journal Article
• Authors: Csupor, Dezső; Widowitz, Ute; Blazsó, Gábor; Laczkó‐Zöld, Eszter; Tatsimo, Joel S. N.; Balogh, Ágnes; Boros, Klára; Dankó, Balázs; Bauer, Rudolf; Hohmann, Judit
• Is Part Of: Phytotherapy research. Volume 27:Number 4(2013:Apr.)
• Page Start: 540
• Page End: 544
• Publication Date: 2012-06-04
• Subjects: Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.4754
• Languages: English
• ISSNs: 0951-418X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Our study aimed at the identification of anti‐inflammatory activities of different fractions of <italic>C. sadleriana</italic> extract after <italic>per os</italic> administration in rats, the identification of the active compounds of the plant and the investigation of the <italic>in vitro</italic> anti‐inflammatory activities of <italic>Centaurea</italic> species native to or cultivated in the Carpathian Basin. The aerial parts of <italic>Centaurea sadleriana</italic> Janka have been used in Hungarian folk medicine to treat the wounds of sheep. Methanol extract of <italic>C. sadleriana</italic> was fractioned by solvent‐solvent partitioning. The <italic>n</italic>‐hexane fraction was further fractionated and the anti‐inflammatory activities of certain subfractions were confirmed <italic>in vivo</italic> in rats. The <italic>n</italic>‐hexane and chloroform fraction of the methanol extract of <italic>C. sadleriana</italic> exhibited remarkable COX‐1 and COX‐2 inhibiting effects <italic>in vitro</italic>. Chromatographic separation of the fractions led to the identification of the active subfractions and 11 compounds (α‐linolenic acid, γ‐linolenic acid, stigmasterol, β‐sitosterol, campesterol, vanillin, pectolinarigenin, salvigenin, hispidulin, chrysoeriol and apigenin). The <italic>in vitro</italic> screening for anti‐inflammatory activities of further <italic>Centaurea</italic> species occurring in the Carpathian Basin (<italic>C. adjarica</italic>, <italic>C. bracteata</italic>, <italic>C. cataonica</italic>, <italic>C. cynaroides</italic>, <italic>C. dealbata</italic>, <italic>C. indurata</italic>, <italic>C. macrocephala</italic>, <italic>C. melitensis</italic>, <italic>C. nigrescens</italic>, <italic>C. ruthenica</italic>) revealed considerable COX‐1 and COX‐2 inhibitory activities. Because <italic>C. sadleriana</italic> is an endangered species native only to the Carpathian Basin, the investigation of more prevalent species is reasonable. Copyright © 2012 John Wiley & Sons, Ltd.</p> </abstract>