Dipeptidyl peptidase‐4 inhibitors and cardiovascular risk: a meta‐analysis of randomized clinical trials. Issue 2 (20th September 2012)

• Record Type: Journal Article
• Authors: Monami, M.; Ahrén, B.; Dicembrini, I.; Mannucci, E.
• Is Part Of: Diabetes, obesity & metabolism. Volume 15:Issue 2(2013:Feb.)
• Page Start: 112
• Page End: 120
• Publication Date: 2012-09-20
• Subjects: Diabetes -- Periodicals; Obesity -- Periodicals; Metabolism -- Disorders -- Periodicals; Clinical pharmacology -- Periodicals; 616.462
• DOI: 10.1111/dom.12000
• Languages: English
• ISSNs: 1462-8902

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="dom12000-sec-0001" sec-type="section"> <title>Aims</title> <p>Preliminary data from randomized trials with metabolic outcomes have shown that treatment with dipeptidyl peptidase‐4 inhibitors (DPP4i) could be associated with a reduced incidence of major cardiovascular events (MACE). The present meta‐analysis is aimed at verifying this protective effect, collecting all available data from randomized trials.</p> </sec> <sec id="dom12000-sec-0002" sec-type="section"> <title>Methods</title> <p>A comprehensive search for published and unpublished trials with a duration ≥24 weeks comparing DPP4i with placebo or other drugs was performed, retrieving all MACE reported as serious adverse events together with death from any cause. Mantel–Haenzel odds ratio (MH–OR) was calculated with random effect models for MACE, myocardial infarction, stroke and mortality. When available, effects on glycated haemoglobin, lipid profile and blood pressure were also assessed and used for the estimation of the modification of risk for myocardial infarction using the UKPDS risk engine.</p> </sec> <sec id="dom12000-sec-0003" sec-type="section"> <title>Results</title> <p>A total of 70 trials, enrolling 41 959 patients with a mean follow‐up of 44.1 weeks, was collected and included in the analysis. The MH–OR (95% Confidence Interval) was 0.71[0.59;0.86], 0.64[0.44;0.94], 0.77[0.48;1.24] and 0.60[0.41;0.88] for MACE, myocardial infarction, stroke and mortality, respectively.</p> </sec> <sec id="dom12000-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Treatment with DPP4i reduces the risk of cardiovascular events (particularly myocardial infarction) and all‐cause mortality in patients with type 2 diabetes. The reduction in the incidence of myocardial infarction is greater than what predicted on the basis of conventional risk factors, suggesting a role for other mechanisms.</p> </sec> </abstract>