Association of KIR genes and HLA‐C alleles with HPV‐related uterine cervical disease in Korean women. Issue 3 (10th February 2013)

• Record Type: Journal Article
• Authors: Song, M. J.; Lee, C. W.; Kim, J. H.; Lee, S. J.; Kim, C. J.; Hur, S. Y.; Park, T. C.; Kim, T. G.; Park, J. S.
• Is Part Of: Tissue antigens. Volume 81:Issue 3(2013)
• Page Start: 164
• Page End: 170
• Publication Date: 2013-02-10
• Subjects: Antigens -- Periodicals; Immunological tolerance -- Periodicals; Immunogenetics -- Periodicals; 571.9645
• DOI: 10.1111/tan.12068
• Languages: English
• ISSNs: 0001-2815

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>This study investigated whether killer‐cell immunoglobulin‐like receptor (KIR) genes and human leukocyte antigen (HLA)‐C alleles, receptors and ligands of natural killer cells are associated with the development of human papillomavirus (HPV)‐related cervical disease in Korean women. Blood samples from 132 women with HPV‐related cervical disease and 159 women without HPV infection were collected for genotyping of KIR genes and HLA‐C alleles. Although no relationship was found between KIR genes and HPV‐related cervical disease, a significant relationship was found between HLA‐C alleles as ligands of KIR and HPV‐related cervical disease. Women with HPV‐related cervical disease were found to be significantly more likely to carry <italic>HLA‐C*0303</italic>, particularly those with HPV 16 or 18 infection, and less likely to carry <italic>HLA‐C*01</italic> compared to women without HPV infection. <italic>HLA‐C*0303</italic> was found to confer susceptibility to HPV‐related cervical disease, whereas <italic>HLA‐C*01</italic> was found to confer a protective effect against HPV‐related cervical disease.</p> </abstract>