Antioxidant and anti‐apoptotic effects of onion (Allium cepa) extract on doxorubicin‐induced cardiotoxicity in rats. Issue 3 (13th October 2011)

• Record Type: Journal Article
• Authors: Alpsoy, Seref; Aktas, Cevat; Uygur, Ramazan; Topcu, Birol; Kanter, Mehmet; Erboga, Mustafa; Karakaya, Osman; Gedikbasi, Asuman
• Is Part Of: Journal of applied toxicology. Volume 33:Issue 3(2013)
• Page Start: 202
• Page End: 208
• Publication Date: 2011-10-13
• Subjects: Toxicology -- Periodicals; Industrial toxicology -- Periodicals; Environmentally induced diseases -- Periodicals; Toxicology -- Periodicals; 615.9005
• DOI: 10.1002/jat.1738
• Languages: English
• ISSNs: 0260-437X

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>The aim of this study was to investigate the antioxidant and anti‐apoptotic effects of onion (<italic>Allium cepa</italic>) extracts (ACE) on doxorubicin (DOX)‐induced cardiotoxicity. The rats in the ACE‐pretreated group were given a daily dose of 1 ml ACE for 14 days. To induce cardiotoxicity, DOX (30 mg kg⁻¹ body weight) was injected intraperitoneally by a single dose and the rats were sacrificed after 48 h. To date, no such studies have been performed on the cardioprotective and anti‐apoptotic potential of ACE on DOX‐induced cardiotoxicity. Our data indicate a significant reduction in the activity of <italic>in situ</italic> identification of apoptosis using terminal dUTP nick end‐labeling in cardiomyocytes of the DOX‐treated group with ACE therapy. The DOX‐treated with ACE groups showed a significant decrease in malondialdehyde levels, and increased activities of superoxide dismutase, glutathione and glutathione peroxidase in comparison with the DOX‐treated group. Creatine kinase, creatine kinase MB, lactate dehydrogenase activities and cardiac troponin I levels were significantly decreased in the DOX + ACE group in comparison with the DOX group. These biochemical and histological disturbances were effectively attenuated on pretreatment with ACE. The present study showed that ACE may be a suitable cardioprotector against toxic effects of DOX. Copyright © 2011 John Wiley &amp; Sons, Ltd.</p> </abstract>