Gender‐specific association of the interleukin 18 gene with symptomatic gallstone disease. Issue 4 (25th March 2013)

• Record Type: Journal Article
• Authors: Shih, Shou‐Chuan; Yang, Horng‐Woei; Chang, Tzu‐Yang; Wang, Horng‐Yuan; Hu, Kuang‐Chun; Chang, Ching‐Wei; Chang, Chen‐Wang; Hung, Chien‐Yuan; Lin, Marie; Chan, Hui‐Wen; Lin, Wen‐Shan; Chang, Shih‐Chuan; Lee, Yann‐Jinn
• Is Part Of: Journal of gastroenterology and hepatology. Volume 28:Issue 4(2013:Apr.)
• Page Start: 744
• Page End: 749
• Publication Date: 2013-03-25
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Liver Diseases -- Periodicals; 616.33
• DOI: 10.1111/jgh.12117
• Languages: English
• ISSNs: 0815-9319

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jgh12117-sec-0001" sec-type="section"> <title>Background and Aim</title> <p>Symptomatic gallstone disease (SGSD) induced several inflammatory responses and affected extrahepatic bile ducts. Although the pathology and environmental risk factors of gallstone disease are well documented, immune or inflammatory responses in SGSD development are still inconclusive. Interleukin 18 (IL18) is a pro‐inflammatory cytokine that plays an important role in immune, infectious, and inflammatory diseases because of the induction of interferon‐γ. In this study, we investigated whether polymorphisms of the <italic>IL18</italic> gene were associated with SGSD susceptibility.</p> </sec> <sec id="jgh12117-sec-0002" sec-type="section"> <title>Methods</title> <p>Genomic DNA was isolated from the whole blood samples of 445 patients with SGSD and 1121 gallstone‐free controls. The <italic>IL18</italic> rs549908T>G, rs5744247C>G, rs187238G>C, rs1946518T>G, and rs360719A>G polymorphisms were genotyped using predeveloped TaqMan allelic discrimination assay.</p> </sec> <sec id="jgh12117-sec-0003" sec-type="section"> <title>Results</title> <p>We found <italic>IL18</italic> rs5744247G allele conferred protection against SGSD in female patients (odds ratio = 0.75, corrected <italic>P</italic>‐value = 0.015). Haplotype analysis revealed that TGGTA protected females from SGSD development (odds ratio = 0.75, corrected <italic>P</italic>‐value = 0.02).</p> </sec> <sec id="jgh12117-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Based on our findings, <italic>IL18</italic> rs5744247C>G polymorphism could be a potential genetic marker to predict SGSD susceptibility in Han Chinese women.</p> </sec> </abstract>