The inhibitory effects of aureobasidin A on Candida planktonic and biofilm cells. Issue 2 (12th August 2012)

• Record Type: Journal Article
• Authors: Tan, H. W.; Tay, S. T.
• Is Part Of: Mycoses. Volume 56:Issue 2(2013)
• Page Start: 150
• Page End: 156
• Publication Date: 2012-08-12
• Subjects: Pathogenic fungi -- Periodicals; Medical mycology -- Periodicals; 616.969
• DOI: 10.1111/j.1439-0507.2012.02225.x
• Languages: English
• ISSNs: 0933-7407

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Summary</title> <p>Aureobasidin A (AbA) is a cyclic depsipeptide antifungal compound that inhibits a wide range of pathogenic fungi. In this study, the <italic>in vitro</italic> susceptibility of 92 clinical isolates of various <italic>Candida</italic> species against AbA was assessed by determining the planktonic and biofilm MICs of the isolates. The MIC₅₀ and MIC₉₀ of the planktonic <italic>Candida</italic> yeast were 1 and 1 μg ml⁻¹, respectively, whereas the biofilm MIC₅₀ and MIC₉₀ of the isolates were 8 and ≥64 μg ml⁻¹ respectively. This study demonstrates AbA inhibition on filamentation and biofilm development of <italic>C. albicans</italic>. The production of short hyphae and a lack of filamentation might have impaired biofilm development of AbA‐treated cells. The AbA resistance of mature <italic>Candidia</italic> biofilms (24 h adherent population) was demonstrated in this study.</p> </abstract>