Dynamic prediction by landmarking in competing risks. (22nd October 2012)

• Record Type: Journal Article
• Authors: Nicolaie, M. A.; van, J. C.; de, T. M.; Putter, H.
• Is Part Of: Statistics in medicine. Volume 32:Number 12(2013)
• Page Start: 2031
• Page End: 2047
• Publication Date: 2012-10-22
• Subjects: Medical statistics -- Periodicals; Statistique médicale -- Périodiques; Statistiques médicales -- Périodiques; 610.727
• DOI: 10.1002/sim.5665
• Languages: English
• ISSNs: 0277-6715

Abstract

<abstract abstract-type="main" id="sim5665-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>We propose an extension of the landmark model for ordinary survival data as a new approach to the problem of dynamic prediction in competing risks with time‐dependent covariates. We fix a set of landmark time points <italic>t</italic>_LM within the follow‐up interval. For each of these landmark time points <italic>t</italic>_LM, we create a landmark data set by selecting individuals at risk at <italic>t</italic>_LM; we fix the value of the time‐dependent covariate in each landmark data set at <italic>t</italic>_LM. We assume Cox proportional hazard models for the cause‐specific hazards and consider smoothing the (possibly) time‐dependent effect of the covariate for the different landmark data sets. Fitting this model is possible within the standard statistical software. We illustrate the features of the landmark modelling on a real data set on bone marrow transplantation. Copyright © 2012 John Wiley &amp; Sons, Ltd.</p> </abstract>