Association mapping of genetic risk factors for chronic wasting disease in wild deer. (30th August 2012)

• Record Type: Journal Article
• Authors: Matsumoto, Tomomi; Samuel, Michael D.; Bollinger, Trent; Pybus, Margo; Coltman, David W.
• Is Part Of: Evolutionary applications. Volume 6:Number 2(2013)
• Page Start: 340
• Page End: 352
• Publication Date: 2012-08-30
• Subjects: Evolution (Biology) -- Periodicals; Genetics -- Periodicals; Natural selection -- Periodicals; Ecology -- Periodicals; 576.8
• DOI: 10.1111/eva.12003
• Languages: English
• ISSNs: 1752-4571

Abstract

<abstract abstract-type="main" id="eva12003-abs-0001"> <title>Abstract</title> <p>Chronic wasting disease (CWD) is a fatal transmissible spongiform encephalopathy affecting North American cervids. We assessed the feasibility of association mapping CWD genetic risk factors in wild white‐tailed deer (<italic>Odocoileus virginianus</italic>) and mule deer (<italic>Odocoileus hemionus</italic>) using a panel of bovine microsatellite markers from three homologous deer linkage groups predicted to contain candidate genes. These markers had a low cross‐species amplification rate (27.9%) and showed weak linkage disequilibrium (&lt;1 cM). Markers near the prion protein and the neurofibromin 1 (<italic>NF1</italic>) genes were suggestively associated with CWD status in white‐tailed deer (<italic>P </italic>=<italic> </italic>0.006) and mule deer (<italic>P </italic>=<italic> </italic>0.02), respectively. This is the first time an association between the <italic>NF1</italic> region and CWD has been reported.</p> </abstract>