Gram‐scale synthesis and efficient purification of 13C‐labeled levoglucosan from 13C glucose§. (14th November 2012)

• Record Type: Journal Article
• Authors: Alexander, Lisa; Hoyt, Caroline; Michalczyk, Ryszard; Wu, Ruilian; Thorn, Dave L.; Silks, L. A. 'Pete'
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 56:Number 1(2013)
• Page Start: 27
• Page End: 29
• Publication Date: 2012-11-14
• Subjects: Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.2978
• Languages: English
• ISSNs: 0362-4803

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p> ¹³C‐Labeled levoglucosan has been synthesized and purified in good yield, and on the gram scale in one step from commercially available ¹³C glucose. This one‐step protocol uses 2‐chloro‐1, 3‐dimethylimidazolinium chloride that serves to selectively activate the anomeric carbon toward substitution reactions. The labeled glucose is then smoothly converted to the anhydroglucose. Purification is efficiently achieved on large scale by chromatography on silica gel.</p> </abstract>