Nicotinamide nucleotide transhydrogenase mRNA expression is related to human obesity12. (16th April 2013)

• Record Type: Journal Article
• Authors: Heiker, John T.; Kern, Matthias; Kosacka, Joanna; Flehmig, Gesine; Stumvoll, Michael; Shang, Edward; Lohmann, Tobias; Dreßler, Miriam; Kovacs, Peter; Blüher, Matthias; Klöting, Nora
• Is Part Of: Obesity. Volume 21:Number 3(2013:Mar.)
• Page Start: 529
• Page End: 534
• Publication Date: 2013-04-16
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20095
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Objective:</title> <p>A spontaneous deletion in the nicotinamide nucleotide transhydrogenase (<italic>Nnt</italic>) gene eliminating exons 7‐11 in C57BL/6J (B6J) mice is associated with reduced glucose‐stimulated insulin secretion <italic>in vitro, </italic> impaired glucose tolerance, higher epigonadal fat mass, and altered susceptibility to diet induced obesity of male B6J mice was proposed. A potential implication for NNT in human adipose tissue distribution has not been investigated so far.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Design and Methods:</title> <p>Therefore, <italic>NNT</italic> mRNA expression in paired human samples of visceral (vis) and subcutaneous (sc) adipose tissue from 221 subjects with a wide range of body mass index (BMI), insulin sensitivity, and glucose tolerance was analyzed.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results:</title> <p> <italic>NNT</italic> mRNA expression is significantly higher in visceral fat of obese patients and correlates with body weight, BMI, % body fat, visceral and sc fat area, waist and hip circumference, and fasting plasma insulin (FPI). Multivariate linear regression analysis revealed visceral <italic>NNT</italic> expression as age and gender independent predictor of BMI, waist circumference, visceral fat area, and % body fat, but not FPI and 2 h OGTT glucose.</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusion:</title> <p>In conclusion, a functional relevance of NNT in the development of human obesity and visceral fat distribution was suggested here.</p> </sec> </abstract>