The insertion/deletion (I/D) polymorphism in the angiotensin‐converting enzyme gene and erectile dysfunction risk: a meta‐analysis. (29th November 2012)

• Record Type: Journal Article
• Authors: Zhang, T.; Li, W. L.; He, X. F.; Wu, Z. Y.; Liu, L. H.; He, S. H.; Wei, A. Y.
• Is Part Of: Andrology. Volume 1:Number 2(2013:Mar.)
• Page Start: 274
• Page End: 280
• Publication Date: 2012-11-29
• Subjects: Andrology -- Periodicals; 616.65
• DOI: 10.1111/j.2047-2927.2012.00029.x
• Languages: English
• ISSNs: 2047-2919

Abstract

<abstract abstract-type="main" xml:lang="en" id="andr29-abs-0001"> <title>Summary</title> <p>Erectile dysfunction (ED) is increasingly recognized as a public health problem. Several studies have reported the influence of the insertion/deletion (I/D) polymorphism in the Angiotensin‐converting enzyme (ACE) gene on ED susceptibility, but the results remain controversial. To derive a more precise estimation of the relationship, a meta‐analysis was conducted using data published previously by other groups. A total of six case‐control studies, including 1039 cases and 927 controls, were selected. The pooled odds ratios (ORs) and respective 95% confidence intervals (CIs) were calculated by comparing the carriers of D‐allele with the wild homozygotes (ID + DD vs. II). Comparisons of other genetic models were also performed (ID + II vs. DD, DD vs. II, DI vs. II and D vs. I). In the overall analysis, no significant association between the polymorphism and ED risk was observed (OR=1.07, 95% CI = 0.84 − 1.37, <italic>p </italic>= 0.575 for ID + DD vs. II). In the subgroup analysis by ethnic, no significant association was detected among Asian, Latino and European for the comparison of ID + DD vs. II (Asian: OR=1.27, 95% CI = 0.89 − 1.81; Latino: OR=0.76, 95% CI = 0.46 − 1.27; European: OR=1.06, 95% CI = 0.67 − 1.66). Results from other comparative genetic models also indicated the lack of associations between this polymorphism and ED risk. In conclusion, this meta‐analysis indicates that the ACE I/D polymorphism might not contribute to the risk of ED.</p> </abstract>