Higher Serum Levels of Interleukin 10 Occur at Onset of Acute Otitis Media Caused by Streptococcus Pneumoniae Compared to Haemophilus Influenzae and Moraxella Catarrhalis. (12th February 2013)

• Record Type: Journal Article
• Authors: Liu, Keyi; Kaur, Ravinder; Almudevar, Anthony; Pichichero, Michael E.
• Is Part Of: Laryngoscope. Volume 123:Number 6(2013:Jun.)
• Page Start: 1500
• Page End: 1505
• Publication Date: 2013-02-12
• Subjects: Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.23973
• Languages: English
• ISSNs: 0023-852X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="lary23973-sec-0001" sec-type="section"> <title>Objectives/Hypothesis</title> <p>Acute otitis media (AOM) involves an inflammatory response to microbes in the middle ear that facilitates clearance of otopathogens. Clinically<italic>, Streptococcus pneumoniae (Spn)</italic> infections of the respiratory tract are characterized by greater inflammatory responses than nontypeable <italic>Haemophilus influenzae (NTHi)</italic> and <italic>Moraxella catarrhalis (Mcat)</italic>. Interleukin 10 (IL‐10) plays an important role in down‐regulating the inflammatory response. We compared serum IL‐10 levels in children before onset, at onset, and after recovery from AOM caused by <italic>Spn, NTHi</italic>, and <italic>Mcat</italic>. We sought to determine if IL‐10 could serve as a biomarker to distinguish AOM caused by <italic>Spn</italic> versus <italic>NTHi</italic> and <italic>Mcat</italic>.</p> </sec> <sec id="lary23973-sec-0002" sec-type="section"> <title>Study Design</title> <p>Prospective, longitudinal study in a primary care pediatric practice in Rochester, NY.</p> </sec> <sec id="lary23973-sec-0003" sec-type="section"> <title>Methods</title> <p>Participants were 54 children, 6 to 30 months of age. Outcomes measured were serum IL‐10 levels when healthy, at onset of AOM, and after recovery from AOM.</p> </sec> <sec id="lary23973-sec-0004" sec-type="section"> <title>Results</title> <p>Serum IL‐10 was elevated when children developed AOM (<italic>P</italic>=0.013) due to infections caused by <italic>Spn</italic> (<italic>P</italic>=0.011) but not AOM caused by <italic>NTHi or Mcat</italic>. Middle ear fluid levels of IL‐10 mirrored those seen in serum but were 10‐fold higher (<italic>P</italic>=0.02). Other effector cytokines in serum: IL‐4, IFN‐γ, and TNF‐alpha, did not show the same increases as IL‐10 at onset of AOM.</p> </sec> <sec id="lary23973-sec-0005" sec-type="section"> <title>Conclusion</title> <p>Our study indicates that AOM caused by <italic>Spn</italic> elicits a significantly higher IL‐10 response compared to <italic>NTHi</italic> and <italic>Mcat</italic> and may prove to be a biomarker of AOM infections by <italic>Spn</italic>.</p> </sec> <sec id="lary23973-sec-0006" sec-type="section"> <title>Level of Evidence</title> <p>4.</p> </sec> </abstract>