Causality and Headache Triggers. Issue 4 (27th March 2013)

• Record Type: Journal Article
• Authors: Turner, Dana P.; Smitherman, Todd A.; Martin, Vincent T.; Penzien, Donald B.; Houle, Timothy T.
• Is Part Of: Headache. Volume 53:Issue 4(2013)
• Page Start: 628
• Page End: 635
• Publication Date: 2013-03-27
• Subjects: Headache -- Periodicals; Headache -- Periodicals; 616.8491
• DOI: 10.1111/head.12076
• Languages: English
• ISSNs: 0017-8748

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="head12076-sec-0001" sec-type="section"> <title>Objective</title> <p>The objective of this study was to explore the conditions necessary to assign causal status to headache triggers.</p> </sec> <sec id="head12076-sec-0002" sec-type="section"> <title>Background</title> <p>The term "headache trigger" is commonly used to label any stimulus that is assumed to cause headaches. However, the assumptions required for determining if a given stimulus in fact has a causal‐type relationship in eliciting headaches have not been explicated.</p> </sec> <sec id="head12076-sec-0003" sec-type="section"> <title>Methods</title> <p>A synthesis and application of Rubin's Causal Model is applied to the context of headache causes. From this application, the conditions necessary to infer that 1 event (trigger) causes another (headache) are outlined using basic assumptions and examples from relevant literature.</p> </sec> <sec id="head12076-sec-0004" sec-type="section"> <title>Results</title> <p>Although many conditions must be satisfied for a causal attribution, 3 basic assumptions are identified for determining causality in headache triggers: (1) constancy of the sufferer, (2) constancy of the trigger effect, and (3) constancy of the trigger presentation. A valid evaluation of a potential trigger's effect can only be undertaken once these 3 basic assumptions are satisfied during formal or informal studies of headache triggers.</p> </sec> <sec id="head12076-sec-0005" sec-type="section"> <title>Conclusions</title> <p>Evaluating these assumptions is extremely difficult or infeasible in clinical practice, and satisfying them during natural experimentation is unlikely. Researchers, practitioners, and headache sufferers are encouraged to avoid natural experimentation to determine the causal effects of headache triggers. Instead, formal experimental designs or retrospective diary studies using advanced statistical modeling techniques provide the best approaches to satisfy the required assumptions and inform causal statements about headache triggers.</p> </sec> </abstract>