Preventing recurrent miscarriage of unknown aetiology. (19th April 2013)

• Record Type: Journal Article
• Authors: Morley, Lara; Shillito, Jayne; Tang, Thomas
• Is Part Of: Obstetrician & gynaecologist. Volume 15:Number 2(2013)
• Page Start: 99
• Page End: 105
• Publication Date: 2013-04-19
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; 618
• DOI: 10.1111/tog.12009
• Languages: English
• ISSNs: 1467-2561

Abstract

<abstract abstract-type="main" xml:lang="en" id="tog12009-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="tog12009-sec-0001" sec-type="section"> <title>Key content</title> <p> <list id="tog12009-list-0001" list-type="bullet"> <list-item> <p>One to three per cent of couples are affected by recurrent miscarriage (defined as more than three consecutive pregnancy losses).</p> </list-item> <list-item> <p>Current interventions are centred on known causes of aetiology.</p> </list-item> <list-item> <p>Recent research on miscarriage of unknown cause has investigated the requirements for successful embryo implantation.</p> </list-item> <list-item> <p>Treatment of immunological risk factors with immunotherapy does not have a strong evidence base.</p> </list-item> <list-item> <p>The overall evidence supporting the use of human chorionic gonadotrophin supplementation during pregnancy is inconclusive.</p> </list-item> <list-item> <p>The efficacy of progesterone as an intervention remains empirical, with further trials under way.</p> </list-item> </list> </p> </sec> <sec id="tog12009-sec-0002" sec-type="section"> <title>Learning objectives</title> <p> <list id="tog12009-list-0002" list-type="bullet"> <list-item> <p>To understand the aetiology of recurrent miscarriage and patient risk factors.</p> </list-item> <list-item> <p>To understand the theoretical pathophysiology underlying miscarriage of unknown aetiology.</p> </list-item> <list-item> <p>To be aware of the potential agents of intervention for recurrent miscarriage and their efficacy.</p> </list-item> </list> </p> </sec> <sec id="tog12009-sec-0003" sec-type="section"> <title>Ethical issues</title> <p> <list id="tog12009-list-0003" list-type="bullet"> <list-item> <p>Treating patients with recurrent miscarriage can be emotive; should women be treated with interventions that have limited evidence‐based clinical efficacy?</p> </list-item> <list-item> <p>How do we manage patients with the psychological impact of recurrent miscarriage?</p> </list-item> </list> </p> </sec> </abstract>