Modification in swallowing and ventilation co‐ordination during hypercapnia, hypoxia, and tachypnea in unrestrained animals. Issue 4 (23rd December 2012)

• Record Type: Journal Article
• Authors: Ghannouchi, I.; Duclos, C.; Marie, J. P.; Verin, E.
• Is Part Of: Neurogastroenterology & motility. Volume 25:Issue 4(2013:Apr.)
• Page Start: 308
• Page End: e247
• Publication Date: 2012-12-23
• Subjects: Gastrointestinal system -- Motility -- Periodicals; Gastrointestinal system -- Innervation -- Periodicals; 616.33
• DOI: 10.1111/nmo.12058
• Languages: English
• ISSNs: 1350-1925

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p> <bold>Background </bold> It has been demonstrated that aspirations could occur during respiratory failure, explained by a lack of co‐ordination between swallowing and ventilation. To test this hypothesis, we examined the co‐ordination of ventilation and swallowing in a completely unrestrained rat model during different level of hypercapnia, during hypoxia, and during tachypnea.</p> <p> <bold>Methods </bold> A total of 50 male Wistar rats (250–350 g) were studied in a barometric plethysmograph to analyze swallowing and ventilation during swallowing, at different gas concentration [room air (G1), 10% of O<sub>2</sub> and 0% of CO<sub>2</sub> (G2), 21% of O<sub>2</sub> and 5% of CO<sub>2</sub> (G3), 21% of O<sub>2</sub> and 10% of CO<sub>2</sub> (G4), tachypnea (G5)].</p> <p> <bold>Key Results </bold> During hypoxia, there was no difference between G2 and G1 regarding the swallowing parameters and ventilatory parameters. During hypercapnia, there was an increase in swallowing during inspiration in G4 (16 ± 20%<italic>P </italic>< 0.01) compared with G1. The analysis of ventilatory parameters during swallowing showed an increase in tidal volume (VT) and mean inspiratory time (VT/TI) (<italic>P </italic>< 0.001) with no change in respiratory cycle duration (TTOT), inspiratory time (TI), and expiratory time (TE) when compared with G1. During tachypnea (G5), the VT decreased (<italic>P </italic>< 0.05) without any change in VT/TI.</p> <p> <bold>Conclusions & Inferences </bold> Our results on animal demonstrated that hypercapnia increased swallowing during inspiration, which was not the case for tachypnea or hypoxia, and could explain some aspirations during respiratory failure.</p> </abstract>