Detection and visualization of intracutaneous allergic type‐specific elements using long‐wavelength near‐infrared hyperspectral imaging. Issue 1 (5th June 2012)

• Record Type: Journal Article
• Authors: Nishino, Ken; Fujiyama, Toshiharu; Hashizume, Hideo; Nakauchi, Shigeki
• Is Part Of: Skin research and technology. Volume 19:Issue 1(2013)
• Page Start: e157
• Page End: e166
• Publication Date: 2012-06-05
• Subjects: Skin -- Research -- Periodicals; Skin -- Diseases -- Periodicals; Skin -- Physiology -- Periodicals; 616.5
• DOI: 10.1111/j.1600-0846.2012.00622.x
• Languages: English
• ISSNs: 0909-752X

Abstract

<abstract abstract-type="main" id="srt622-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="srt622-sec-0001" sec-type="section"> <title>Background/purpose</title> <p>This study aimed to develop a method for the assessment of allergic dermatitis by using the long‐wavelength near‐infrared spectrum (more than 1000 nm) to detect intracutaneous allergic type‐specific elements. Such a method was realized by establishing a spectral classifier for the spectra of type I and type IV allergic dermatitis reactions.</p> </sec> <sec id="srt622-sec-0002" sec-type="section"> <title>Methods</title> <p>Near‐infrared spectral images of histamine‐induced cutaneous reaction (type I) and contact hypersensitivity erythema elicited by squaric acid dibutylester (SADBE; type IV) were obtained, and the absorption spectra of normal and inflamed skin were extracted from these spectral images. A spectral classifier was established from these training datasets, and it was then applied to two test cases, red flare by methyl nicotinate (normal) and metal allergy (type IV).</p> </sec> <sec id="srt622-sec-0003" sec-type="section"> <title>Results</title> <p>The spectral classifier established by canonical discriminant analysis (CDA) achieved very accurate detection (normal: 87.67%, type I: 87.00%, type IV: 98.5%). Furthermore, the test cases were also correctly classified: the red flare induced by methyl nicotinate was categorized as normal skin and the metal allergy was categorized as a type IV allergic reaction.</p> </sec> <sec id="srt622-sec-0004" sec-type="section"> <title>Conclusions</title> <p>These results suggest a possible application of near‐infrared spectral imaging to the assessment of allergic dermatitis.</p> </sec> </abstract>