Effect of rapid fluid resuscitation using crystalloids or colloids on hemostasis in piglets. Issue 3 (29th December 2012)

• Record Type: Journal Article
• Authors: Mauch, Jacqueline; Madjdpour, Caveh; Kutter, Annette P. N.; Spielmann, Nelly; Bettschart‐Wolfensberger, Regula; Weiss, Markus; Haas, Thorsten; Anderson, Brian
• Is Part Of: Paediatric anaesthesia. Volume 23:Issue 3(2013)
• Page Start: 258
• Page End: 264
• Publication Date: 2012-12-29
• Subjects: Pediatric anesthesia -- Periodicals; 617.96798
• DOI: 10.1111/pan.12106
• Languages: English
• ISSNs: 1155-5645

Abstract

<abstract abstract-type="main" id="pan12106-abs-0001"> <title>Summary</title> <sec id="pan12106-sec-0001" sec-type="section"> <title>Background and Objectives</title> <p>Impairment of blood coagulation is one of the main side effects of volume replacement, particularly if artificial colloids such as hydroxyethyl starch (HES) and gelatine preparations are used. This animal study aimed to evaluate the effect of a single fast intravenous crystalloid or colloid fluid bolus on blood coagulation as measured by rotation thromboelastometry (ROTEM<sup>®</sup>).</p> </sec> <sec id="pan12106-sec-0002" sec-type="section"> <title>Methods</title> <p>Thirty‐two anesthetized piglets were infused with a rapid 20 ml·kg<sup>−1</sup> fluid bolus of either normal saline (NS), 4% gelatine, 5% albumin or 6% HES 130/0.4 (<italic>n</italic> = 8 per group) over a period of 2 min. Hemostasis was assessed by ROTEM<sup>®</sup> before and 1 min after fluid administration. Within‐group differences were analyzed by Wilcoxon test, and additionally overall Kruskal–Wallis test followed by posthoc Mann–Whitney <italic>U</italic>‐test were applied to detect differences between groups.</p> </sec> <sec id="pan12106-sec-0003" sec-type="section"> <title>Results</title> <p>All fluids caused a significant weakening of clot strength within groups. HES and gelatine showed a significantly stronger impairment of clot growth and maximum clot firmness as compared with albumin and normal saline. Impairment of fibrin polymerization was more pronounced following HES as compared with all other fluids.</p> </sec> <sec id="pan12106-sec-0004" sec-type="section"> <title>Conclusion</title> <p>After moderate but very fast volume loading, HES and gelatine impair blood coagulation to a larger extent as compared with albumin or normal saline, while no significant differences were observed between both artificial colloids.</p> </sec> </abstract>