Efficacy of topical calcineurin inhibitors in vitiligo. (20th January 2013)

• Record Type: Journal Article
• Authors: Wong, Russell; Lin, Andrew N.
• Is Part Of: International journal of dermatology. Volume 52:Number 4(2013:Apr.)
• Page Start: 491
• Page End: 496
• Publication Date: 2013-01-20
• Subjects: Dermatology -- Periodicals; 616.5
• DOI: 10.1111/j.1365-4632.2012.05697.x
• Languages: English
• ISSNs: 0011-9059

Abstract

<abstract abstract-type="main" id="ijd5697-abs-0001"> <title>Abstract</title> <p>Topical tacrolimus and pimecrolimus are indicated for the treatment of atopic dermatitis, but they have been studied in many off‐label uses. We reviewed the English language literature to define their roles in treatment of vitiligo. Double‐blind studies show that tacrolimus 0.1% ointment combined with excimer laser is superior to placebo, especially for UV resistant areas, such as bony prominences of the extremities. When used alone, tacrolimus 0.1% ointment is almost as effective as clobetasol propionate 0.05% ointment. Other studies suggest it can also be effective for facial lesions. Double blind studies show that pimecrolimus 1% cream combined with narrow band UVB is superior to placebo, especially for facial lesions. Additional studies would further clarify the role of topical calcineurin inhibitors in vitiligo.</p> </abstract>