Biomechanical properties of novel biodegradable poly ε‐caprolactone–chitosan scaffolds. Issue 1 (27th August 2012)

• Record Type: Journal Article
• Authors: Thuaksuban, Nuttawut; Nuntanaranont, Thongchai; Suttapreyasri, Srisurang; Pattanachot, Wachirapan; Sutin, Kanyarat; Cheung, Lim Kwong
• Is Part Of: Journal of investigative and clinical dentistry. Volume 4:Issue 1(2013:Feb.)
• Page Start: 26
• Page End: 33
• Publication Date: 2012-08-27
• Subjects: Dentistry -- Periodicals; Mouth -- Diseases -- Periodicals; Mouth Diseases -- Periodicals; Tooth Diseases -- Periodicals; 617.6
• DOI: 10.1111/j.2041-1626.2012.00131.x
• Languages: English
• ISSNs: 2041-1618

Abstract

<abstract abstract-type="main" id="jicd131-abs-0001"> <title>Abstract</title> <sec id="jicd131-sec-0001" sec-type="section"> <title>Aim</title> <p>To investigate the biomechanical properties of poly ε‐caprolactone (PCL)–chitosan (CS) scaffolds fabricated by the melt stretching and multilayer deposition technique.</p> </sec> <sec id="jicd131-sec-0002" sec-type="section"> <title>Methods</title> <p>The PCL–CS scaffolds containing CS at 0% (pure PCL), 10%, and 20% by weight were prepared. For the monolayer scaffolds, shear and blending tests simulating the reconstruction of orbital floor defects (situation A) and mandibular defects (situation B) were conducted. For the 3‐D scaffolds, compression tests of their superior and lateral aspects were done.</p> </sec> <sec id="jicd131-sec-0003" sec-type="section"> <title>Results</title> <p>For the monolayer scaffolds, the pure PCL group had remarkably lower shear strength than the other groups (<italic>P </italic>><italic> </italic>0.05). In situation A, all groups withstood the forces without any significant difference. In situation B, the pure PCL group could withstand the forces remarkably lower than those of the other group (<italic>P </italic><<italic> </italic>0.05). The 3‐D scaffolds of all groups could withstand compressive forces directed towards their superior aspects. However, they could not withstand the forces directed towards their lateral aspects at the limited strain.</p> </sec> <sec id="jicd131-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The monolayer scaffolds were suitable for reconstruction of the orbital floor and mandibular defects under light load‐bearing conditions. The 3‐D scaffolds could be used in the high load bearing‐areas only if the forces were directed at their superior aspects.</p> </sec> </abstract>