A randomized controlled trial of mindfulness‐based cognitive therapy for bipolar disorder. (9th December 2012)

• Record Type: Journal Article
• Authors: Perich, T.; Manicavasagar, V.; Mitchell, P. B.; Ball, J. R.; Hadzi‐Pavlovic, D.
• Is Part Of: Acta psychiatrica Scandinavica. Volume 127:Number 5(2013:May)
• Page Start: 333
• Page End: 343
• Publication Date: 2012-12-09
• Subjects: Psychiatry -- Periodicals; 616.89
• DOI: 10.1111/acps.12033
• Languages: English
• ISSNs: 0001-690X

Abstract

<abstract abstract-type="main" id="acps12033-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="acps12033-sec-0001" sec-type="section"> <title>Objective</title> <p>To compare the efficacy of mindfulness‐based cognitive therapy (MBCT) plus treatment as usual (TAU) to TAU alone for patients with bipolar disorder over a 12‐month follow‐up period.</p> </sec> <sec id="acps12033-sec-0002" sec-type="section"> <title>Method</title> <p>Participants with a DSM‐IV diagnosis of bipolar disorder were randomly allocated to either MBCT plus TAU or TAU alone. Primary outcome measures were time to recurrence of a DSM‐IV major depressive, hypomanic or manic episode; the Montgomery‐Åsberg Depression Rating Scale (MADRS); and Young Mania Rating Scale (YMRS). Secondary outcome measures were number of recurrences, the Depression Anxiety Stress Scales (DASS), and the State Trait Anxiety Inventory (STAI).</p> </sec> <sec id="acps12033-sec-0003" sec-type="section"> <title>Results</title> <p>Ninety‐five participants with bipolar disorder were recruited to the study (MBCT = 48; TAU = 47). Intention‐to‐treat (ITT) analysis found no significant differences between the groups on either time to first recurrence of a mood episode or total number of recurrences over the 12‐month period. Furthermore, there were no significant between‐group differences on the MADRS or YMRS scales. A significant between‐group difference was found in STAI – state anxiety scores. There was a significant treatment by time interaction for the DAS – achievement subscale.</p> </sec> <sec id="acps12033-sec-0004" sec-type="section"> <title>Conclusion</title> <p>While MBCT did not lead to significant reductions in time to depressive or hypo/manic relapse, total number of episodes, or mood symptom severity at 12‐month follow‐up, there was some evidence for an effect on anxiety symptoms. This finding suggests a potential role of MBCT in reducing anxiety comorbid with bipolar disorder.</p> </sec> </abstract>