Copy number variations identified in the chicken using a 60K SNP BeadChip. (23rd November 2012)

• Record Type: Journal Article
• Authors: Jia, X.; Chen, S.; Zhou, H.; Li, D.; Liu, W.; Yang, N.
• Is Part Of: Animal genetics. Volume 44:Number 3(2013:Jun.)
• Page Start: 276
• Page End: 284
• Publication Date: 2012-11-23
• Subjects: Animal genetics -- Periodicals; 572.8
• DOI: 10.1111/age.12009
• Languages: English
• ISSNs: 0268-9146

Abstract

<abstract abstract-type="main" id="age12009-abs-0001"> <title>Summary</title> <p>Copy number variation (CNV) is considered an important genetic variation, contributing to many economically important traits in the chicken. Although CNVs can be detected using a comparative genomic hybridization array, the high‐density SNP array has provided an alternative way to identify CNVs in the chicken. In the current study, a chicken 60K SNP BeadChip was used to identify CNVs in two distinct chicken genetic lines (White Leghorn and dwarf) using the <sc>penncnv</sc> program. A total of 209 CNV regions were identified, distributing on chromosomes 1–22 and 24–28 and encompassing 13.55 Mb (1.42%) of chicken autosomal genome area. Three of seven selected CNVs (73.2% individuals) were completely validated by quantitative PCR. To our knowledge, this is the first report in the chicken identifying CNVs using a SNP array. Identification of 190 new identified CNVs illustrates the feasibility of the chicken 60K SNP BeadChip to detect CNVs in the chicken, which lays a solid foundation for future analyses of associations of CNVs with economically important phenotypes in chickens.</p> </abstract>