The effects of a 1.8 GHz continuous electromagnetic fields on mucociliary transport of human nasal mucosa1. (11th October 2012)

• Record Type: Journal Article
• Authors: In, Seung Min; Kim, Hyun Jun; Park, Rae Woong; Kim, Woojae; Gimm, Yoon‐Myoung; Park, Ikmo; Hong, Sungpyo; Hong, Jeong Joo; Oh, Jeong Hyun; Kahng, Hison; Park, Eun Young
• Is Part Of: Laryngoscope. Volume 123:Number 2(2013:Feb.)
• Page Start: 315
• Page End: 320
• Publication Date: 2012-10-11
• Subjects: Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.23620
• Languages: English
• ISSNs: 0023-852X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Objectives/Hypothesis:</title> <p>The aim of this study was to investigate the effects of a 1.8 GHz continuous electromagnetic fields (EMF) on human nasal mucociliary transport, and to determine the pathophysiology of ciliary beat frequency (CBF) during an EMF‐induced change.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Methods:</title> <p>Human nasal mucosa cells were exposed to a 1.8 GHz EMF (SAR=1.0 W/kg), and CBF was analyzed using an optical flow technique with the peak detection method.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results:</title> <p>The 1.8 GHz‐exposed group showed a decreased CBF when compared to the control group. In the cytotoxicity assay, difference in survival rates was not found between the two groups. In the EMF‐exposed group, protein kinase C (PKC) activity was increased during a PKC activity assay. The broad PKC inhibitor, Calphostin C abolished the EMF‐induced decrease of CBF. The EMF‐induced decrease of CBF was abolished by GF 109203X, a novel PKC (nPKC) isoform inhibitor, whereas the decrease was not attenuated by Gö‐6976, a specific inhibitor of conventional PKC (cPKC) isoform.</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusions:</title> <p>EMF may inhibit CBF via an nPKC‐dependent mechanism. Therefore, we have confirmed that EMF could decrease CBF by increasing PKC activity. Laryngoscope, 2012</p> </sec> </abstract>