Body Fat Distribution and Risk Factors for Fibrosis in Patients with Alcoholic Liver Disease. (7th September 2012)

• Record Type: Journal Article
• Authors: Naveau, Sylvie; Dobrin, Anca‐Stela; Balian, Axel; Njiké‐Nakseu, Micheline; Nohra, Pascal; Asnacios, Amani; Prévot, Sophie; Perlemuter, Gabriel
• Is Part Of: Alcoholism. Volume 37:Number 2(2013:Feb.)
• Page Start: 332
• Page End: 338
• Publication Date: 2012-09-07
• Subjects: Alcoholism -- Periodicals; Alcoholism -- Periodicals; Alcoolisme; Electronic journals; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.861005
• DOI: 10.1111/j.1530-0277.2012.01927.x
• Languages: English
• ISSNs: 0145-6008

Abstract

<abstract abstract-type="main" id="acer1927-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="acer1927-sec-0001" sec-type="section"> <title>Background</title> <p>Only a small proportion of alcoholic patients develop advanced liver disease, suggesting that factors other than alcohol intake may influence alcoholic liver disease (ALD) progression. We have shown that body mass index (BMI) is an independent risk factor for fibrosis in alcohol‐induced liver disease and that adipose tissue inflammation is correlated with liver lesions in alcoholic patients. The aim of this study was to determine whether visceral adipose tissue, as assessed by abdominal height measurement, affected individual susceptibility to fibrosis in alcoholic patients.</p> </sec> <sec id="acer1927-sec-0002" sec-type="section"> <title>Methods</title> <p>We included 127 consecutive alcoholic patients with abnormal liver test findings for whom liver histology data were available. Abdominal height was measured with a Holtain‐Kahn abdominal caliper. We carried out univariate comparisons followed by multivariate regression analysis, to investigate the relationship between abdominal height and fibrosis score.</p> </sec> <sec id="acer1927-sec-0003" sec-type="section"> <title>Results</title> <p>Abdominal height (<italic>p</italic> < 0.005), waist circumference (<italic>p</italic> < 0.05), fasting blood glucose concentration (<italic>p</italic> < 0.05), serum triglyceride concentration (<italic>p</italic> < 0.05), serum bilirubin (<italic>p</italic> < 0.005), and BMI (<italic>p</italic> = 0.05) were higher, whereas high‐density lipoprotein (HDL) cholesterol level (<italic>p</italic> < 0.01) was lower in the 72 patients with significant (F2–F4) fibrosis than in the 55 patients with F0–F1 fibrosis. In multivariate regression analysis, only abdominal height (β = 7.2, <italic>p</italic> < 0.002) was independently and positively correlated with fibrosis score, which was also negatively correlated with HDL cholesterol level (β = −1.04, <italic>p</italic> < 0.05).</p> </sec> <sec id="acer1927-sec-0004" sec-type="section"> <title>Conclusions</title> <p>We provide the first demonstration that abdominal height may be a predictor of significant fibrosis in patients with ALD. Our findings support a role for visceral fat accumulation, independent of BMI and of metabolic syndrome criteria, in the onset of alcoholic liver damage.</p> </sec> </abstract>